Simple sequence repeats: genetic modulators of brain function and behavior

被引：91

作者：

Fondon, John W., III ^{[3
,4
]}

Hammock, Elizabeth A. D. ^{[5
]}

Hannan, Anthony J. ^{[6
,7
]}

King, David G. ^{[1
,2
]}

机构：

[1] So Illinois Univ Carbondale, Dept Anat, Carbondale, IL 62901 USA

[2] So Illinois Univ Carbondale, Dept Zool, Carbondale, IL 62901 USA

[3] Univ Texas SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

[4] Univ Texas SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

[5] Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN 37232 USA

[6] Univ Melbourne, Howard Florey Inst, Melbourne, VIC 3010, Australia

[7] Univ Melbourne, Dept Anat & Cell Biol, Melbourne, VIC 3010, Australia

来源：

TRENDS IN NEUROSCIENCES | 2008年 / 31卷 / 07期

关键词：

D O I：

10.1016/j.tins.2008.03.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Simple sequence repeats (SSRs), sometimes described as genetic 'stutters,' are DNA tracts in which a short base-pair motif is repeated several to many times in tandem (e.g. CAGCAGCAG). These sequences experience frequent mutations that alter the number of repeats. Because SSRs are commonly located in promoters, untranslated regions and even coding sequences, such mutations can directly influence almost any aspect of gene function. Mutational expansion of certain triplet repeats is responsible for several hereditary neurodegenerative disorders, but SSR alleles can also contribute to normal variation in brain and behavioral traits. Here we review studies implicating SSRs not just in disease but also in circadian rhythmicity, sociosexual interaction, aggression, cognition and personality. SSRs can affect neuronal differentiation, brain development and even behavioral evolution.

引用

页码：328 / 334

页数：7

共 72 条

[1]

BEALE R, 2006, IMPLICIT GENOME, P177

[2] The mGIuR theory of fragile X mental retardation [J].

Bear, MF ;

Huber, KM ;

Warren, ST .

TRENDS IN NEUROSCIENCES, 2004, 27 (07) :370-377

[3] Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking [J].

Benjamin, J ;

Li, L ;

Patterson, C ;

Greenberg, BD ;

Murphy, DL ;

Hamer, DH .

NATURE GENETICS, 1996, 12 (01) :81-84

[4] Early experience and serotonin transporter gene variation interact to influence primate CNS function [J].

Bennett, AJ ;

Lesch, KP ;

Heils, A ;

Long, JC ;

Lorenz, JG ;

Shoaf, SE ;

Champoux, M ;

Suomi, SJ ;

Linnoila, MV ;

Higley, JD .

MOLECULAR PSYCHIATRY, 2002, 7 (01) :118-122

[5] Anxious behavior and fenfluramine-induced prolactin secretion in young rhesus macaques with different alleles of the serotonin reuptake transporter polymorphism (5HTTLPR) [J].

Bethea, CL ;

Streicher, JM ;

Coleman, K ;

Pau, FKY ;

Moessner, R ;

Cameron, JL .

BEHAVIOR GENETICS, 2004, 34 (03) :295-307

[6] Natural selection and the emergence of a mutation phenotype: An update of the evolutionary synthesis considering mechanisms that affect genome variation [J].

Caporale, LH .

ANNUAL REVIEW OF MICROBIOLOGY, 2003, 57 :467-485

[7] Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene [J].

Caspi, A ;

Sugden, K ;

Moffitt, TE ;

Taylor, A ;

Craig, IW ;

Harrington, H ;

McClay, J ;

Mill, J ;

Martin, J ;

Braithwaite, A ;

Poulton, R .

SCIENCE, 2003, 301 (5631) :386-389

[8] Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates [J].

Champoux, M ;

Bennett, A ;

Shannon, C ;

Higley, JD ;

Lesch, KP ;

Suomi, SJ .

MOLECULAR PSYCHIATRY, 2002, 7 (10) :1058-1063

[9] Myotonic dystrophy: Emerging mechanisms for DM1 and DM2 [J].

Cho, Diane H. ;

Tapscott, Stephen J. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2007, 1772 (02) :195-204

[10] CAG repeat instability at SCA2 locus: anchoring CAA interruptions and linked single nucleotide polymorphisms [J].

Choudhry, S ;

Mukerji, M ;

Srivastava, AK ;

Jain, S ;

Brahmachari, SK .

HUMAN MOLECULAR GENETICS, 2001, 10 (21) :2437-2446

← 1 2 3 4 5 6 7 8 →