Reduced membrane-bound catechol-O-methyltransferase in the liver of spontaneously hypertensive rats

被引：27

作者：

Tsunoda, M

Tenhunen, J

Tilgmann, C

Arai, H

Imai, K

机构：

[1] Kyoritsu Coll Pharmaceut Sci, Ctr Res & Dev, Minato Ku, Tokyo 1058512, Japan

[2] Univ Tokyo, Lab BioAnalyt Chem, Grad Sch Pharmaceut Sci, Tokyo, Japan

[3] Univ Tokyo, Lab Hlth Chem, Grad Sch Pharmaceut Sci, Tokyo, Japan

[4] Orion Pharma, Helsinki, Finland

[5] Kyoritsu Coll Pharmaceut Sci, Ctr Res & Dev, Tokyo, Japan

来源：

HYPERTENSION RESEARCH | 2003年 / 26卷 / 11期

关键词：

catecholamine; catechol-O-methyltransferase; liver; membrane-bound;

D O I：

10.1291/hypres.26.923

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

We have previously reported that methylation of catecholamines by catechol-O-methyltransferase (COMT) was attenuated in spontaneously hypertensive rats (SHR) with acute hypotension as compared with that of Wistar-Kyoto (WKY) rats. Here we examined the soluble (S-) and membrane-bound (MB-) COMT activities and COMT protein in the liver, kidney, and erythrocytes in both strains. Both the activities and the amounts of MB-COMT in the liver were lower in SHR than in WKY rats, but no such trend was found in the kidney or erythrocytes. Nor was such a trend observed in any of these three tissues for S-COMT. These results indicate that liver MB-COMT may be a relevant factor in blood pressure regulation in rats.

引用

页码：923 / 927

页数：5

共 23 条

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