Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence

被引：28

作者：

Holder, JR ^{[1
]}

Bauzo, RM ^{[1
]}

Xiang, ZM ^{[1
]}

Scott, J ^{[1
]}

Haskell-Luevano, C ^{[1
]}

机构：

[1] Univ Florida, Dept Med Chem, Gainesville, FL 32610 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 24期

关键词：

D O I：

10.1016/j.bmcl.2003.08.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-substituted glycine oligomers (peptoids) and peptide-peptoid hybrids were synthesized based on the Ac-His-Phe-Arg-Trp-NH2 tetrapeptide template. The compounds were pharmacologically characterized at the mouse melanocortin receptors (MC1R, MC3R-MC5R) for agonist activity. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：4505 / 4509

页数：5

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