Association of serum bilirubin with pulsatile arterial function in asymptomatic young adults: the Bogalusa Heart Study

被引:30
作者
Bhuiyan, Azad R. [1 ]
Srinivasan, Sathanur R. [1 ]
Chen, Wei [1 ]
Sultana, Aqfa [1 ]
Berenson, Gerald S. [1 ]
机构
[1] Tulane Univ, Hlth Sci Ctr, Tulane Ctr Cardiovasc Hlth, New Orleans, LA 70112 USA
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 2008年 / 57卷 / 05期
关键词
D O I
10.1016/j.metabol.2007.12.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The inverse association between serum bilirubin, a potent antioxidant, and oxidative stress-mediated diseases like cardiovascular disease is known. However, information is scant regarding the influence of bilirubin in relation to traditional cardiovascular risk factors on pulsatile arterial function in asymptomatic younger adults. The present study examines this aspect in 777 black and white subjects (71% white, 42% male) aged 18 to 44 years. Pulsatile arterial function was assessed in terms of large-artery (capacitive) and small-artery (oscillatory) compliances by radial artery pressure pulse contour analysis. In bivariate analysis adjusted for race and sex, bilirubin related significantly and positively to large- and small-artery compliances and high-density lipoprotein cholesterol, and inversely to age, body mass index, blood pressure variables, non-high-density lipoprotein cholesterol, triglycerides, and insulin resistance index. In multivariable analysis including race, sex, body surface area, and risk factor variables mentioned above, bilirubin did not relate to large-artery compliance, without or with smoking status in the model, whereas bilirubin associated beneficially with small-artery compliance (P = .01) in a model that excluded smoking status. When smoking status was included in the model, this association became less strong (P = .04); and smoking entered the model as an adverse predictor (P = .003). The observed beneficial association of serum bilirubin on pulsatile arterial function, albeit the attenuating effect of smoking on this relationship, in asymptomatic younger adults supports the antioxidant function of bilirubin in providing protection against oxidative stress-mediated vascular dysfunction. (C) 2008 Published by Elsevier Inc.
引用
收藏
页码:612 / 616
页数:5
相关论文
共 42 条
[1]   The pathophysiology of cigarette C-V smoking and cardiovascular disease - An update [J].
Ambrose, JA ;
Barua, RS .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (10) :1731-1737
[2]   BILIRUBIN INHIBITS PROTEIN-KINASE-C ACTIVITY AND PROTEIN-KINASE C-MEDIATED PHOSPHORYLATION OF ENDOGENOUS SUBSTRATES IN HUMAN SKIN FIBROBLASTS [J].
AMIT, Y ;
BONEH, A .
CLINICA CHIMICA ACTA, 1993, 223 (1-2) :103-111
[3]   ARTERIAL STIFFNESS - A NEW CARDIOVASCULAR RISK FACTOR [J].
ARNETT, DK ;
EVANS, GW ;
RILEY, WA .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1994, 140 (08) :669-682
[4]   Distribution and correlates of arterial compliance measures in asymptomatic young adults: The Bogalusa Heart Study [J].
Bhuiyan, AR ;
Li, SX ;
Li, H ;
Chen, W ;
Srinivasan, SR ;
Berenson, GS .
AMERICAN JOURNAL OF HYPERTENSION, 2005, 18 (05) :684-691
[5]   Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients [J].
Blacher, J ;
Asmar, R ;
Djane, S ;
London, GM ;
Safar, ME .
HYPERTENSION, 1999, 33 (05) :1111-1117
[6]  
*BOG HEART STUD, 1995, AM J MED SCI, V310, pS1
[7]   NONINVASIVE PULSE-WAVE ANALYSIS FOR THE EARLY DETECTION OF VASCULAR-DISEASE [J].
COHN, JN ;
FINKELSTEIN, S ;
MCVEIGH, G ;
MORGAN, D ;
LEMAY, L ;
ROBINSON, J ;
MOCK, J .
HYPERTENSION, 1995, 26 (03) :503-508
[8]   Total serum bilirubin and risk of cardiovascular disease in the Framingham Offspring Study [J].
Djoussé, L ;
Levy, D ;
Cupples, LA ;
Evans, JC ;
D'Agostino, RB ;
Ellison, RC .
AMERICAN JOURNAL OF CARDIOLOGY, 2001, 87 (10) :1196-+
[9]   Tissue angiotensin and pathobiology of vascular disease - A unifying hypothesis [J].
Dzau, VJ .
HYPERTENSION, 2001, 37 (04) :1047-1052
[10]   Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women [J].
Erdogan, D ;
Gullu, H ;
Yildirim, E ;
Tok, D ;
Kirbas, I ;
Ciftci, O ;
Baycan, ST ;
Muderrisoglu, H .
ATHEROSCLEROSIS, 2006, 184 (02) :431-437