2-dimethylarsinothioyl acetic acid identified in a biological sample: The first occurrence of a mammalian arsinothioyl metabolite

被引：71

作者：

Hansen, HR

Pickford, R

Thomas-Oates, J

Jaspars, M

Feldmann, J

机构：

[1] Univ Aberdeen, Dept Chem, Coll Phys Sci, Old Aberdeen AB24 3UE, Scotland

[2] Univ Aberdeen, Sch Biosci, Aberdeen AB24 3UE, Scotland

[3] Univ York, Dept Chem, York YO10 3RA, N Yorkshire, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 03期

关键词：

analytical methods; arsenic; bioinorganic chemistry; mass spectrometry; sulfur;

D O I：

10.1002/anie.200352740

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Arsenic in sheep's clothing: the first characterization of a thio-organoarsenate compound (2-dimethylarsinothioyl acetic acid) isolated from a biological source (a rare breed of seaweed-eating sheep; see picture) is reported. The result indicates that mammalian arsenic metabolism is much more complex than has been claimed before, which opens up new questions about the toxicity of such organoarsenothio(y)l compounds.

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页码：337 / 340

页数：4

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