High Levels of Anti-Cyclic Citrullinated Peptide Autoantibodies Are Associated with Co-occurrence of Pulmonary Diseases with Rheumatoid Arthritis

被引：94

作者：

Aubart, Fleur ^{[1
]}

Crestani, Bruno ^{[2
]}

Nicaise-Roland, Pascale ^{[3
]}

Tubach, Florence ^{[4
,5
]}

Bollet, Caroline ^{[1
]}

Dawidowicz, Karen ^{[1
]}

Quintin, Emilie ^{[1
]}

Hayem, Gilles ^{[1
]}

Palazzo, Elisabeth ^{[1
]}

Meyer, Olivier ^{[1
]}

Chollet-Martin, Sylvie ^{[3
,6
]}

Dieude, Philippe ^{[1
,7
]}

机构：

[1] Univ Paris 07, Hop Bichat Claude Bernard, Dept Rheumatol, APHP, F-75018 Paris, France

[2] Univ Paris 07, Hop Bichat Claude Bernard, Pneumol Dept A, APHP, F-75018 Paris, France

[3] Univ Paris 07, Hop Bichat Claude Bernard, Dept Immunol, APHP, F-75018 Paris, France

[4] Univ Paris 07, Hop Bichat Claude Bernard, Dept Epidemiol, F-75018 Paris, France

[5] Univ Paris 07, INSERM, UMR 756, F-75018 Paris, France

[6] Univ Paris Sud, INSERM, UMRS 996, Chatenay Malabry, France

[7] Paris Diderot Univ, INSERM U699, Paris, France

来源：

JOURNAL OF RHEUMATOLOGY | 2011年 / 38卷 / 06期

关键词：

ANTI-CYCLIC CITRULLINATED PEPTIDE AUTOANTIBODIES; PULMONARY DISEASE; RHEUMATOID ARTHRITIS; LUNG-DISEASE; EXTRAARTICULAR MANIFESTATIONS; ANTIBODIES; CLASSIFICATION; CRITERIA;

D O I：

10.3899/jrheum.101261

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objective. To investigate whether levels of anti-cyclic citrullinated peptide antibodies (anti-CCP2) in patients with rheumatoid arthritis (RA) are associated with the co-occurrence of lung diseases. Methods. A total of 252 RA patients were included in a cross-sectional study. Pulmonary disease was confirmed by high-resolution chest computed tomography scan. Circulating anti-CCP2 were quantified using ELISA. Multivariate logistic regression was conducted to identify independent risk factors for lung disease. Results. Male sex (OR 3.29, 95% CI 1.59-6.80) and high anti-CCP2 levels (OR 1.49, 95% CI 1.25-1.78) were identified as independent risk factors for lung disease in the RA population. Conclusion. High anti-CCP2 levels are associated with lung disease in the RA population. (First Release March 1 2011; J Rheumatol 2011;38:979-82; doi:10.3899/jrheum.101261)

引用

页码：979 / 982

页数：4

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