Treatment of acute Nipah encephalitis with ribavirin

被引：152

作者：

Chong, HT

Kamarulzaman, A

Tan, CT ^{[1
]}

Goh, KJ

Thayaparan, T

Kunjapan, R

Chew, NK

Chua, KB

Lam, SK

机构：

[1] Univ Malaya, Med Ctr, Neurol Lab, Dept Med, Kuala Lumpur 59100, Malaysia

[2] Univ Malaya, Med Ctr, Dept Microbiol, Kuala Lumpur 59100, Malaysia

[3] Seremban Hosp, Dept Med, Negeri Sembilan, Malaysia

来源：

ANNALS OF NEUROLOGY | 2001年 / 49卷 / 06期

关键词：

D O I：

10.1002/ana.1062

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Nipah virus, a newly identified paramyxovirus caused a severe outbreak of encephalitis in Malaysia with high fatalities. We report an open-label trial of ribavirin in 140 patients, with 54 patients who were managed prior to the availability of ribavirin or refused treatment as control. There were 45 deaths (32%) in the ribavirin arm; 29 deaths (54%) occurred in the control arm. This represents a 36% reduction in mortality (p = 0.011). There was no associated serious side effect. This study suggests that ribavirin is able to reduce the mortality of acute Nipah encephalitis.

引用

页码：810 / 813

页数：4

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