Cell-division inhibitors: new insights for future antibiotics

被引：213

作者：

Lock, Rowena L. ^{[1
]}

Harry, Elizabeth J. ^{[1
]}

机构：

[1] Univ Technol Sydney, Inst Biotechno Infect Dis, Sydney, NSW 2007, Australia

来源：

NATURE REVIEWS DRUG DISCOVERY | 2008年 / 7卷 / 04期

关键词：

D O I：

10.1038/nrd2510

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The growing problem of antibiotic resistance has been exacerbated by the use of new drugs that are merely variants of older overused antibiotics. While it is naive to expect to restrain the spread of resistance without controlling antibacterial usage, the desperate need for drugs with novel targets has been recognized by health organizations, industry and academia alike. The wealth of knowledge available about the bacterial cell-division pathway has aided target-driven approaches to identify novel inhibitors. Here, we discuss the therapeutic potential of inhibiting bacterial cell division, and review the progress made in this exciting new area of antibacterial discovery.

引用

页码：324 / 338

页数：15

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