Polarization of PAR Proteins by Advective Triggering of a Pattern-Forming System

被引：234

作者：

Goehring, Nathan W. ^{[2
]}

Trong, Philipp Khuc ^{[1
,2
]}

Bois, Justin S. ^{[1
,2
]}

Chowdhury, Debanjan ^{[1
]}

Nicola, Ernesto M. ^{[1
]}

Hyman, Anthony A. ^{[2
]}

Grill, Stephan W. ^{[1
,2
]}

机构：

[1] Max Planck Inst Phys Complex Syst MPI PKS, D-01187 Dresden, Germany

[2] Max Planck Inst Mol Cell Biol & Genet MPI CBG, D-01307 Dresden, Germany

来源：

SCIENCE | 2011年 / 334卷 / 6059期

关键词：

C-ELEGANS EMBRYOS; ANTERIOR-POSTERIOR POLARITY; CELL POLARITY; CAENORHABDITIS-ELEGANS; CORTICAL FLOWS; ESTABLISHMENT; MAINTENANCE; ASYMMETRY; ZYGOTE;

D O I：

10.1126/science.1208619

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the Caenorhabditis elegans zygote, a conserved network of partitioning-defective (PAR) polarity proteins segregates into an anterior and a posterior domain, facilitated by flows of the cortical actomyosin meshwork. The physical mechanisms by which stable asymmetric PAR distributions arise from transient cortical flows remain unclear. We present evidence that PAR polarity arises from coupling of advective transport by the flowing cell cortex to a multistable PAR reaction-diffusion system. By inducing transient PAR segregation, advection serves as a mechanical trigger for the formation of a PAR pattern within an otherwise stably unpolarized system. We suggest that passive advective transport in an active and flowing material may be a general mechanism for mechanochemical pattern formation in developmental systems.

引用

页码：1137 / 1141

页数：6

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