Synthesis of new peptidic glycoclusters derived from β-alanine.: Part 2:: Optionally modulated distance between side-chain branched points

被引：10

作者：

Hada, N ^{[1
]}

Sato, K ^{[1
]}

Jin, Y ^{[1
]}

Takeda, T ^{[1
]}

机构：

[1] Kyoritsu Univ Pharm, Minato Ku, Tokyo 1058512, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2005年 / 53卷 / 09期

关键词：

glycocluster; omega-amino acid; D-galactose; glycodendron; unit synthesis;

D O I：

10.1248/cpb.53.1131

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of an asymmetric glycocluster 1 has been achieved using two glycocluster units 12 and 13, prepared by coupling the cluster chain unit 4 with each omega-amino acid (beta-alanine and 6-aminocapronic acid) trichloroethyl ester, and peptidic C-terminal block glycocluster 16, prepared by,coupling the bifunctional linker 14 with sugar unit 9. This method facilitated the synthesis of the cluster optionally modulated the distance between the side-chain branched points by using various omega-amino acids. We also synthesized glycodendron 2 using the same intermediate.

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页码：1131 / 1135

页数：5

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