Role of folate receptor genes in reproduction and related cancers

被引：81

作者：

Elnakat, H ^{[1
]}

Ratnam, M ^{[1
]}

机构：

[1] Med Coll Ohio, Dept Biochem & Canc Biol, Toledo, OH 43614 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2006年 / 11卷

关键词：

folate receptor; glycosyl phosphatidylinositol; ovary; cancer; tumor; glucocorticoid receptor; estrogen receptor; review;

D O I：

10.2741/1815

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression patterns of folate receptor (FR) isoforms, alpha and beta, in normal and malignant male and female reproductive tissues is described. The significance of the receptor in reproductive and developmental physiology is discussed. The potential value of the receptor expressed in malignant tissues including ovarian and endometrial cancers as a diagnostic marker and a therapeutic target is reviewed. Finally, the various transcriptional and post-transcriptional mechanisms that govern the tissue/tumor-specificity of the receptor and its regulation by folate and steroid receptor ligands are described; the potential value of this knowledge in developing better methods for the early detection and treatment of certain cancers is discussed.

引用

页码：506 / 519

页数：14

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