Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex

被引：6

作者：

Bence, AK

Rogers, DT

Worthen, DR

Fu, M

Littleton, JM

Crooks, PA ^{[1
]}

机构：

[1] Univ Kentucky, Coll Pharm, Div Pharmaceut Sci, Lexington, KY 40536 USA

[2] Univ Kentucky, Coll Med, Dept Pharmacol, Lexington, KY 40536 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(00)00530-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As part of a drug discovery program using high-throughput radioligand-binding assays, aminoanthraquinones were identified as potential modulators of N-methyl-D-aspartate (NMDA) receptor function. Aminoanthraquinones may represent a novel class of polyamine binding site ligands with a unique pharmacophore and may facilitate the rational design of novel NMDA-receptor modulators. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2621 / 2623

页数：3

共 19 条

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