Evidence for an enhancement of excitatory transmission in adult CNS by Wnt signaling pathway modulation

被引：35

作者：

Beaumont, Vahri ^{[1
]}

Thompson, Sally-Anne

Choudhry, Fahd

Nuthall, Hugh

Glantschnig, Helmut

Lipfert, Lorraine

David, Gabriela R.

Swain, Christopher J.

McAllister, George

Munoz-Sanjuan, Ignacio

机构：

[1] Univ Calif Los Angeles, Dept Neurobiol, 650 Charles E Young Dr S, Los Angeles, CA 90095 USA

[2] Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Harlow CM20 2QR, Essex, England

[3] Merck Res Labs, West Point, PA 19486 USA

[4] Amgen Inc, San Francisco, CA 94080 USA

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2007年 / 35卷 / 04期

关键词：

D O I：

10.1016/j.mcn.2007.03.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role for Wnt signaling modulation during synaptogenesis, neurogenesis and cell fate specification have been well characterized. In contrast, the roles for Wnt signaling pathways in the regulation of synaptic plasticity and adult physiology are only starting to be elucidated. Here, we have identified a novel series of Wnt pathway small molecule modulators, and report that these and other small molecules targeting the Wnt pathway acutely enhance excitatory transmission in adult hippocampal preparations. Our findings are consistent with a pre- and postsynaptic site of action, leading to both increased spontaneous and evoked neurotransmission that occurs in a transcription-independent fashion. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：513 / 524

页数：12

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