The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses

被引：146

作者：

Tumpey, Terrence M.

Szretter, Kristy J.

Van Hoeven, Neal

Katz, Jacqueline M.

Kochs, Georg

Haller, Otto

Garcia-Sastre, Adolfo

Staeheli, Peter

机构：

[1] Univ Freiburg, Dept Virol, D-79104 Freiburg, Germany

[2] Ctr Dis Control, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA 30333 USA

[3] CUNY Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA

[4] CUNY Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA

[5] CUNY Mt Sinai Sch Med, Div Infect Dis, Emerging Pathogens Inst, New York, NY 10029 USA

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 19期

关键词：

D O I：

10.1128/JVI.01116-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mice carrying a wild-type Mx1 gene (Mx1(+/+)) differ from standard laboratory mice (Mx1(-/-)) in being highly resistant to infection with common laboratory strains of influenza A virus. We report that Mx1 also protects mice against the pandemic human 1918 influenza virus and a highly lethal human H5N1 strain from Vietnam. Resistance to H5N1 of Mx1(+/+) but not Mx1(-/-) mice was enhanced if the animals were treated with a single dose of exogenous alpha interferon before infection. Thus, the interferon-induced resistance factor Mx1 represents a key component of the murine innate immune system that mediates protection against epidemic and pandemic influenza viruses.

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收藏

页码：10818 / 10821

页数：4

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