Synthesis of 1-hydroxybicyclo[n.1.0]alkanes (n=3 and 4) and their silyl ethers from olefinic esters via tandem intramolecular nucleophilic acyl substitution and intramolecular carbonyl addition reactions mediated by Ti(OPr-i)(4)/2 i-PrMgCl reagent

被引：52

作者：

Kasatkin, A ^{[1
]}

Kobayashi, K ^{[1
]}

Okamoto, S ^{[1
]}

Sato, F ^{[1
]}

机构：

[1] TOKYO INST TECHNOL, DEPT BIOMOLEC ENGN, MIDORI KU, YOKOHAMA, KANAGAWA 226, JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 11期

关键词：

D O I：

10.1016/0040-4039(96)00160-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of olefinic esters with Ti(OPr-i)(4)/2 i-PrMgCl reagent resulted in intramolecular nucleophilic acyl substitution and successive intramolecular carbonyl addition reactions providing 1-hydroxybicyclo[n.1.0]alkanes (n = 3 and 4) in high yields.

引用

页码：1849 / 1852

页数：4

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