Change in biomarkers of type-2 inflammation following severe exacerbations of asthma

被引：14

作者：

Semprini, Ruth ^{[1
,2
]}

Shortt, Nick ^{[1
,2
]}

Ebmeier, Stefan ^{[1
]}

Semprini, Alex ^{[1
,2
]}

Varughese, Rachel ^{[1
]}

Holweg, Cecile T. J. ^{[3
]}

Matthews, John G. ^{[3
]}

Fingleton, James ^{[1
,4
]}

Weatherall, Mark ^{[1
,4
,5
]}

Beasley, Richard ^{[1
,2
,4
]}

Braithwaite, Irene ^{[1
,4
]}

机构：

[1] Med Res Inst New Zealand, Wellington 6242, New Zealand

[2] Victoria Univ Wellington, Wellington, New Zealand

[3] Genentech Inc, San Francisco, CA 94080 USA

[4] Capital & Coast Dist Hlth Board, Wellington, New Zealand

[5] Univ Otago, Wellington, New Zealand

来源：

THORAX | 2019年 / 74卷 / 01期

关键词：

asthma; OMALIZUMAB;

D O I：

10.1136/thoraxjnl-2018-211657

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

We investigated the time course of change of type-2 asthma biomarkers after a severe asthma exacerbation. Blood eosinophils were lowest immediately after treatment was initiated (0.07 vs 0.33x10(9)/L, p<0.001) while serum IgE levels were at their highest (339 vs 249 U/L, p<0.001). Fractional exhaled Nitric Oxide levels were lowest 2 weeks after treatment (23 vs 33 ppb, p=0.06) and serum periostin levels were lowest 1 week after treatment (45 center dot 9 vs 50 center dot 9 ng/mL, p<0.001). A delay of 4-8 weeks following a severe exacerbation is required if these biomarkers are used to guide the ongoing management of patients with asthma.

引用

页码：95 / 98

页数：4

共 9 条

[1]

Predicting and evaluating response to omalizumab in patients with severe allergic asthma [J].

Bousquet, J. ;

Rabe, K. ;

Humbert, M. ;

Chung, K. F. ;

Berger, W. ;

Fox, H. ;

Ayre, G. ;

Chen, H. ;

Thomas, K. ;

Blogg, M. ;

Holgate, S. .

RESPIRATORY MEDICINE, 2007, 101 (07) :1483-1492

[2]

Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial [J].

Brightling, Christopher E. ;

Chanez, Pascal ;

Leigh, Richard ;

O'Byrne, Paul M. ;

Korn, Stephanie ;

She, Dewei ;

May, Richard D. ;

Streicher, Katie ;

Ranade, Koustubh ;

Piper, Edward .

LANCET RESPIRATORY MEDICINE, 2015, 3 (09) :692-701

[3]

Lebrikizumab Treatment in Adults with Asthma [J].

Corren, Jonathan ;

Lemanske, Robert F., Jr. ;

Hanania, Nicola A. ;

Korenblat, Phillip E. ;

Parsey, Merdad V. ;

Arron, Joseph R. ;

Harris, Jeffrey M. ;

Scheerens, Heleen ;

Wu, Lawren C. ;

Su, Zheng ;

Mosesova, Sofia ;

Eisner, Mark D. ;

Bohen, Sean P. ;

Matthews, John G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (12) :1088-1098

[4]

Exploring the Effects of Omalizumab in Allergic Asthma An Analysis of Biomarkers in the EXTRA Study [J].

Hanania, Nicola A. ;

Wenzel, Sally ;

Rosen, Karin ;

Hsieh, Hsin-Ju ;

Mosesova, Sofia ;

Choy, David F. ;

Lal, Preeti ;

Arron, Joseph R. ;

Harris, Jeffrey M. ;

Busse, William .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187 (08) :804-811

[5]

Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies [J].

Ortega, Hector G. ;

Yancey, Steven W. ;

Mayer, Bhabita ;

Gunsoy, Necdet B. ;

Keene, Oliver N. ;

Bleecker, Eugene R. ;

Brightling, Christopher E. ;

Pavord, Ian D. .

LANCET RESPIRATORY MEDICINE, 2016, 4 (07) :549-556

[6]

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma [J].

Ortega, Hector G. ;

Liu, Mark C. ;

Pavord, Ian D. ;

Brusselle, Guy G. ;

FitzGerald, J. Mark ;

Chetta, Alfredo ;

Humbert, Marc ;

Katz, Lynn E. ;

Keene, Oliver N. ;

Yancey, Steven W. ;

Chanez, Pascal .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (13) :1198-1207

[7]

An Official American Thoracic Society/European Respiratory Society Statement: Asthma Control and Exacerbations Standardising Endpoints for Clinical Asthma Trials and Clinical Practice [J].

Reddel, Helen K. ;

Taylor, D. Robin ;

Bateman, Eric D. ;

Boulet, Louis-Philippe ;

Boushey, Homer A. ;

Busse, William W. ;

Casale, Thomas B. ;

Chanez, Pascal ;

Enright, Paul L. ;

Gibson, Peter G. ;

de Jongste, Johan C. ;

Kerstjens, Huib A. M. ;

Lazarus, Stephen C. ;

Levy, Mark L. ;

O'Byrne, Paul M. ;

Partridge, Martyn R. ;

Pavord, Ian D. ;

Sears, Malcolm R. ;

Sterk, Peter J. ;

Stoloff, Stuart W. ;

Sullivan, Sean D. ;

Szefler, Stanley J. ;

Thomas, Mike D. ;

Wenzel, Sally E. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 180 (01) :59-99

[8]

Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications [J].

Robinson, D. ;

Humbert, M. ;

Buhl, R. ;

Cruz, A. A. ;

Inoue, H. ;

Korom, S. ;

Hanania, N. A. ;

Nair, P. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2017, 47 (02) :161-175

[9]

Wenzel S, 2016, EUR RESP J S60, V48, P1798

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