Expression and immunogenicity of the C-terminus of a major blood-stage surface protein of Plasmodium vivax, Pv200(19), secreted from Saccharomyces cerevisiae

被引:24
作者
Kaslow, DC [1 ]
Kumar, S [1 ]
机构
[1] NIAID,MALARIA VACCINES SECT,PARASIT DIS LAB,NIH,BETHESDA,MD 20892
关键词
Plasmodium vivax; congenic; merozoite surface protein 1; vaccine;
D O I
10.1016/0165-2478(96)02570-9
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The carboxy-terminus of the major merozoite surface protein of Plasmodium has been shown to be the target of protective immunity in a number of non-vivax malaria parasite species. In an effort to develop a protective vaccine for Plasmodium vivax, the most prevalent form of human malaria, we expressed in Saccharomyces cerevisiae the 19-kDa a carboxy-terminus of Pv200 as a His(6)-tagged, secreted polypeptide. Five of seven H-2 congenic mouse strains elicited antibodies that recognized yeast produced PV200(19) by ELISA. The vaccine appears to be immunogenic and widely recognized, and to contain one or more helper T cell epitopes that may allow boosting with subsequent natural infections.
引用
收藏
页码:187 / 189
页数:3
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