Late neointimal tissue growth behind the stent after intravascular γ-radiation

被引:7
作者
Busseuil, D
Zeller, M [1 ]
Cottin, Y
Maingon, P
Barillot, I
Allouch, P
Ponnelle, T
Bril, A
Briot, F
Wolf, JE
Rochette, L
机构
[1] CHU Bocage, Serv Cardiol, Dept Cardiol, F-21034 Dijon, France
[2] Univ Burgundy, Fac Med, Lab Cardiovasc & Expt Physiopathol & Pharmacol, Dijon, France
[3] CGFL, Dept Radiotherapy, Dijon, France
[4] Univ Hosp, Dept Pathol, Dijon, France
[5] CEA, Valduc, France
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2004年 / 58卷 / 01期
关键词
stents; restenosis; fibrin deposition; incomplete apposition;
D O I
10.1016/S0360-3016(03)00817-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To determine the nature of the changes of the vascular wall after intravascular brachytherapy in stented arteries leading to incomplete stent apposition. Methods and Materials: Stents were implanted in the infrarenal aortas of rabbits, and gamma-intravascular brachytherapy (18 Gy) or a sham radiation procedure was immediately implemented. The arteries were harvested at 6 months for histologic analyses. Results: The external elastic lamina area, as well as the vascular wall area behind the stent, were significantly greater in irradiated vs. control arteries (8.94 +/- 0.68 mm(2) vs. 6.87 +/- 0.40 mm(2) [p <0.001] and 1.56 +/- 0.13 mm(2) vs. 0.72 +/- 0.07 mm(2) [P <0.001], respectively). The ratio of the intimal area behind the stent related to the total intimal area was greater in the irradiated segments (control vs. irradiated: 9.0% +/- 5.9% vs. 55.3% +/- 15.5%, p <0.05). Neointimal growth of the irradiated vessels outside the stent was characterized by marked fibrin depositions and an inflammatory response around the stent struts. Conclusion: Our study revealed the presence of a neointimal layer specifically located behind the stent, which represented the result of an unhealed fibrin-rich tissue growth process 6 months after intravascular brachytherapy. (C) 2004 Elsevier Inc.
引用
收藏
页码:259 / 266
页数:8
相关论文
共 32 条
[1]   Safety of intracoronary γ-radiation on uninjured reference segments during the first 6 months after treatment of in-stent restenosis -: A serial intravascular ultrasound study [J].
Ahmed, JM ;
Mintz, GS ;
Waksman, R ;
Weissman, NJ ;
Mehran, R ;
Pichard, AD ;
Satler, LF ;
Kent, KM ;
Leon, MB .
CIRCULATION, 2000, 101 (19) :2227-2230
[2]   Use of intravascular ultrasound in the endovascular management of atherosclerotic aortoiliac occlusive disease [J].
Arko, F ;
McCollough, R ;
Manning, L ;
Buckley, C .
AMERICAN JOURNAL OF SURGERY, 1996, 172 (05) :546-550
[3]   Intravascular radiation and scenting: Absence of efficacy on intimal proliferation in a rabbit model [J].
Busseuil, D ;
Zeller, M ;
Cottin, Y ;
Allouch, P ;
Maingon, P ;
Barillot, I ;
Naudy, S ;
Arnould, L ;
Michalowicz, G ;
Moisant, M ;
Horiot, JC ;
Wolf, JE ;
Rochette, L .
CARDIOVASCULAR DRUGS AND THERAPY, 2000, 14 (06) :695-697
[4]  
Castagna MT, 2001, CIRCULATION, V103, P778
[5]  
Condado JA, 1997, CIRCULATION, V96, P727
[6]  
Costa MA, 2000, J INVASIVE CARDIOL, V12, P113
[7]  
Cottin Y, 2001, Cardiovasc Radiat Med, V2, P75, DOI 10.1016/S1522-1865(00)00078-0
[8]   Vascular repair after balloon overstretch injury in porcine model effects of intracoronary radiation [J].
Cottin, Y ;
Kollum, M ;
Chan, R ;
Bhargava, B ;
Vodovotz, Y ;
Waksman, R .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (04) :1389-1395
[9]   Novel drug-delivery stent - Intravascular ultrasound observations from the first human experience with the QP2-eluting polymer stent system [J].
Honda, Y ;
Grube, E ;
de la Fuente, LM ;
Yock, PG ;
Stertzer, SH ;
Fitzgerald, PJ .
CIRCULATION, 2001, 104 (04) :380-383
[10]   Positive geometric vascular remodeling is seen after catheter-based radiation followed by conventional stent implantation but not after radioactive stent implantation [J].
Kay, IP ;
Sabaté, M ;
Costa, MA ;
Kozuma, K ;
Albertal, M ;
van der Giessen, WJ ;
Wardeh, AJ ;
Ligthart, JMR ;
Coen, VMA ;
Levendag, PC ;
Serruys, PW .
CIRCULATION, 2000, 102 (12) :1434-1439