Activation of metalloproteinase-2, loss of matrix scleroprotein content and coronary artery calcification

被引：16

作者：

Kieffer, P

Giummelly, P

Schjoth, B

Carteaux, JP

Villemot, JP

Hornebeck, W

Atkinson, J

机构：

[1] UHP Nancy, Pharmacol Lab, EA 3116, F-54000 Nancy, France

[2] CHRU Nancy, Serv Chirurg & Transplantat Cariothorac, F-54511 Vandoeuvre Nancy, France

[3] Fac Med, Lab Biol Mol & Biochim Med, CNRS, UPRESA 6021, F-51000 Reims, France

来源：

ATHEROSCLEROSIS | 2001年 / 157卷 / 01期

关键词：

atheroma; arteriosclerosis; calcium; matrix metalloproteinases; scleroproteins;

D O I：

10.1016/S0021-9150(00)00704-8

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Plaques from the coronary arteries of explanted hearts showed massive calcification (15-fold increase) with a loss of scleroproteins ( - 36%), an increase in the collagen to elastin ratio (twofold) and activation (+ 15%) of matrix metalloproteinase-2 (MMP-2). Plaque-free portions of the coronary artery gave results similar to those obtained with the internal mammary artery. There was a significant correlation between plaque calcification and MMP-2 activation, suggesting that the two processes may be linked. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：251 / 254

页数：4

共 15 条

[1]

Atkinson J, 1999, PATHOL BIOL, V47, P677

[2]

Matrix proteins and mineralization: An overview [J].