Artificial beta-sheets

被引：98

作者：

Nowick, JS

Smith, EM

Pairish, M

机构：

来源：

CHEMICAL SOCIETY REVIEWS | 1996年 / 25卷 / 06期

关键词：

D O I：

10.1039/cs9962500401

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Within the past decade, several research groups have synthesized and studied compounds that mimic the structures and hydrogen-bonding patterns of beta-sheets. In these compounds, rigid molecular templates stabilize beta-sheet structure in attached peptides. Through these studies, these researchers hope to gain an enhanced understanding of protein structure and develop useful peptidomimetic building blocks. This review seeks to summarize these studies and explain the growing interest in artificial beta-sheets.

引用

收藏

页码：401 / &

页数：16

相关论文

共 42 条

[1]

ADANG AEP, 1994, RECL TRAV CHIM PAY B, V113, P63

[2] PEPTIDOMIMETICS AND SMALL-MOLECULE DRUG DESIGN - TOWARDS IMPROVED BIOAVAILABILITY AND IN-VIVO STABILITY [J].

BEELEY, N .

TRENDS IN BIOTECHNOLOGY, 1994, 12 (06) :213-216

[3] ANTIPARALLEL BETA-SHEET CONFORMATION IN CYCLOPEPTIDES CONTAINING A PSEUDO-AMINO ACID WITH A BIPHENYL MOIETY [J].

BRANDMEIER, V ;

SAUER, WHB ;

FEIGEL, M .

HELVETICA CHIMICA ACTA, 1994, 77 (01) :70-85

[4]

Creighton TE, 1993, PROTEINS STRUCTURES

[5] A DIBENZOFURAN-BASED AMINO-ACID DESIGNED TO NUCLEATE ANTIPARALLEL BETA-SHEET STRUCTURE - EVIDENCE FOR INTRAMOLECULAR HYDROGEN-BOND FORMATION [J].

DIAZ, H ;

ESPINA, JR ;

KELLY, JW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (21) :8316-8318

[6]

DYSON HJ, 1991, ANNU REV BIOPHYS BIO, V20, P519

[7] 2,8-DIMETHYL-4-(CARBOXYMETHYL)-6-(AMINOMETHYL)PHENOXATHIIN S-DIOXIDE - AN ORGANIC SUBSTITUTE FOR THE BETA-TURN IN PEPTIDES [J].

FEIGEL, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (01) :181-182

[8]

GANTE J, 1994, ANGEW CHEM INT EDIT, V33, P1699, DOI 10.1002/anie.199416991

[9] AN ACHIRAL DIPEPTIDE MIMETIC THAT PROMOTES BETA-HAIRPIN FORMATION [J].

GARDNER, RR ;

LIANG, GB ;

GELLMAN, SH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (11) :3280-3281

[10] PEPTIDOMIMETICS FOR RECEPTOR LIGANDS DISCOVERY, DEVELOPMENT, AND MEDICAL PERSPECTIVES [J].

GIANNIS, A .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1993, 32 (09) :1244-1267

← 1 2 3 4 5 →