Cardiovascular involvement in rheumatoid arthritis

被引:28
作者
Gerli, R
Goodson, NJ
机构
[1] Univ Perugia, Rheumatol Unit, Dept Clin & Expt Med, I-06100 Perugia, Italy
[2] Univ Perugia, Ctr Study Rheumat Dis, Dept Clin & Expt Med, I-06100 Perugia, Italy
[3] Univ Liverpool, Hosp Aintree, Sch Clin Sci, Acad Rheumatol Dept, Liverpool L69 3BX, Merseyside, England
关键词
atherosclerosis; cardiovascular system; heart; rheumatoid arthritis;
D O I
10.1191/0961203305lu2199oa
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cardiovascular (CV) disease morbidity and mortality are increased in patients with rheumatoid arthritis (RA) and much of the excess CV disease morbidity appears to be due to atherosclerosis. The pathogenesis of atherosclerosis (ATS) in RA is complex and there is increasing evidence that many factors including novel and traditional cardiovascular risk factors, RA treatments and the RA inflammatory disease process are involved in the development of CV disease in these patients. Of particular interest are the effects of chronic inflammation and immune dysregulation associated with RA. These have been shown to be associated with endothelial dysfunction, which is an early, potentially reversible, functional abnormality of the arterial wall. However, as several CV disease risk factors and drug prescribing are also influenced by RA disease severity it is very difficult to separate out the effects of the inflammatory disease burden on the cardiovascular system in RA.
引用
收藏
页码:679 / 682
页数:4
相关论文
共 31 条
[1]  
Björnådal L, 2002, J RHEUMATOL, V29, P906
[2]   Influence of glucocorticoids and disease activity on total and high density lipoprotein cholesterol in patients with rheumatoid arthritis [J].
Boers, M ;
Nurmohamed, MT ;
Doelman, CJA ;
Lard, LR ;
Verhoeven, AC ;
Voskuyl, AE ;
Huizinga, TWJ ;
van de Stadt, RJ ;
Dijkmans, BAC ;
van der Linden, S .
ANNALS OF THE RHEUMATIC DISEASES, 2003, 62 (09) :842-845
[3]   Methotrexate and mortality in patients with rheumatoid arthritis:: a prospective study [J].
Choi, HK ;
Hernán, MA ;
Seeger, JD ;
Robins, JM ;
Wolfe, F .
LANCET, 2002, 359 (9313) :1173-1177
[4]   Effect of glucocorticoids on the arteries in rheumatoid arthritis [J].
del Rincón, I ;
O'Leary, DH ;
Haas, RW ;
Escalante, A .
ARTHRITIS AND RHEUMATISM, 2004, 50 (12) :3813-3822
[5]  
del Rincón I, 2001, ARTHRITIS RHEUM-US, V44, P2737, DOI 10.1002/1529-0131(200112)44:12<2737::AID-ART460>3.0.CO
[6]  
2-#
[7]  
Dessein PH, 2005, J RHEUMATOL, V32, P435
[8]   Is there any future for tumor necrosis factor antagonists in chronic heart failure? [J].
Feldman A.M. ;
McTiernan C. .
American Journal of Cardiovascular Drugs, 2004, 4 (1) :11-19
[9]   Survival in rheumatoid arthritis - A population-based analysis of trends over 40 years [J].
Gabriel, SE ;
Crowson, CS ;
Kremers, HM ;
Doran, MF ;
Turesson, C ;
O'Fallon, WM ;
Matteson, EL .
ARTHRITIS AND RHEUMATISM, 2003, 48 (01) :54-58
[10]   CD4+CD28-T lymphocytes contribute to early atherosclerotic damage in rheumatoid arthritis patients [J].
Gerli, R ;
Schillaci, G ;
Giordano, A ;
Bocci, EB ;
Bistoni, O ;
Vaudo, G ;
Marchesi, S ;
Pirro, M ;
Ragni, F ;
Shoenfeld, Y ;
Mannarino, E .
CIRCULATION, 2004, 109 (22) :2744-2748