Potential usefulness of basic fibroblast growth factor as a treatment for stroke

被引:71
作者
Ay, H [1 ]
Ay, I
Koroshetz, WJ
Finklestein, SP
机构
[1] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
关键词
cerebral ischemia; ischemic stroke; basic fibroblast growth factor; neuroprotection; recovery;
D O I
10.1159/000015941
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Within the past few years, a growing body of evidence has accumulated indicating that exogenously administered neurotrophic growth facto rs may limit the extent of acute ischemic neural injury and enhance functional neurorecovery following stroke. One of the most widely studied growth factor in this regard is basic fibroblast growth factor (bFGF). In preclinical studies, bFGF administered intravenously within hours after the onset of ischemia reduces infarct size, presumably due to direct protection of cells at the borders (penumbra) of cerebral infarction. On the other hand, if bFGF is administered intracisternally starting at one day after ischemia, infarct size is not reduced, but recovery of sensorimotor function of the impaired limbs is increased, presumably due to enhancement of new neuronal sprouting and synapse formation in the intact uninjured brain. Clinical trials of the intravenous administration of bFGF as a cytoprotective agent in acute stroke are in progress. Trials of the delayed administration of bFGF as a recovery-promoting agent in subacute stroke are anticipated.
引用
收藏
页码:131 / 135
页数:5
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