Cytotoxic Chemotherapy and CD4+Effector T Cells: An Emerging Alliance for Durable Antitumor Effects

被引：45

作者：

Ding, Zhi-Chun ^{[1
]}

Zhou, Gang ^{[1
,2
]}

机构：

[1] Georgia Hlth Sci Univ, Canc Immunotherapy Program, Ctr Canc, Augusta, GA 30912 USA

[2] Georgia Hlth Sci Univ, Hematol Oncol Sect, Dept Med, Sch Med, Augusta, GA 30912 USA

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2012年

关键词：

TUMOR-INFILTRATING LYMPHOCYTES; DISSEMINATED MURINE LEUKEMIA; MYELOID SUPPRESSOR-CELLS; DRAINING LYMPH-NODES; DENDRITIC CELLS; IN-VIVO; IMMUNE-RESPONSE; B-CELL; ADOPTIVE IMMUNOTHERAPY; MEDIATED SUPPRESSION;

D O I：

10.1155/2012/890178

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Standard cytotoxic chemotherapy can initially achieve high response rates, but relapses often occur in patients and represent a severe clinical problem. As increasing numbers of chemotherapeutic agents are found to have immunostimulatory effects, there is a growing interest to combine chemotherapy and immunotherapy for synergistic antitumor effects and improved clinical benefits. Findings from recent studies suggest that highly activated, polyfunctional CD4+ effector T cells have tremendous potential in strengthening and sustaining the overall host antitumor immunity in the postchemotherapy window. This review focuses on the latest progresses regarding the impact of chemotherapy on CD4+ T-cell phenotype and function and discusses the prospect of exploiting CD4+ T cells to control tumor progression and prevent relapse after chemotherapy.

引用

页数：12

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