Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation

被引：16

作者：

Zhang, RX

Wang, LB

Liu, B

Qiao, JT

Ren, K

Berman, BM

Lao, LX

机构：

[1] Univ Maryland, Sch Med, Ctr Integrat Med, James Kernan Hosp Mans, Baltimore, MD 21207 USA

[2] Shanxi Med Univ, Dept Neurobiol, Shanxi 030001, Peoples R China

[3] Univ Maryland, Sch Dent, Dept Biomed Sci, Baltimore, MD 21201 USA

来源：

BRAIN RESEARCH | 2005年 / 1048卷 / 1-2期

关键词：

hyperalgesia; pain; acupuncture; spinal cord; dermorphin-saporin; rat;

D O I：

10.1016/j.brainres.2005.05.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm-sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifically decreases MOR and blocks EA anti-hyperalgesia. These data Suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：235 / 240

页数：6

共 30 条

[1]

[Anonymous], 1999, CHINESE ACUPUNCTURE

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