Selective deprotection of phthalyl protected amines

被引：20

作者：

Costello, CA ^{[1
]}

Kreuzman, AJ ^{[1
]}

Zmijewski, MJ ^{[1
]}

机构：

[1] LILLY RES LABS,LILLY CORP CTR,INDIANAPOLIS,IN 46285

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 42期

关键词：

D O I：

10.1016/0040-4039(96)01752-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phthalyl amidase selectively deprotects phthalimido groups under very mild aqueous conditions in a one-pot reaction to produce phthalic acid and the free amine. The enzyme has been shown to deprotect several primary amines of distinctly different structure, and exhibits chiral selectivity when the substrate contains extensive beta-branching. The enzyme has a definite requirement for ortho positioning of the functional groups on a fixed axis of rotation. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：7469 / 7472

页数：4

共 9 条

[1] SYNTHESIS OF OLIGOSACCHARIDES OF 2-AMINO-2-DEOXY SUGARS [J].