Biology and genetics of malignant brain tumours

被引：4

作者：

Darling, JL ^{[1
]}

Warr, TJ ^{[1
]}

机构：

[1] UCL, Natl Hosp Neurol & Neurosurg, Neurol Inst, Dept Neurosurg, London WC1N 3BG, England

来源：

CURRENT OPINION IN NEUROLOGY | 1998年 / 11卷 / 06期

关键词：

D O I：

10.1097/00019052-199812000-00002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Conventional therapies such as surgery, radiotherapy and, to a lesser extent, chemotherapy have produced significant increases in survival in patients with some types of brain tumours such as medulloblastoma. However, in many other types of brain tumour in both adults and children, the effect of these modalities has been more modest. A thorough understanding of the biology of malignant brain tumours is likely to provide the background for the development of new leads that might be amenable to therapeutic exploitation. This review examines some aspects of glioma biology that have been reported in the past 12 months, and which might be translated into clinical application. Curr Opin Neurol 11:619-625. (C) 1998 Lippincott Williams & Wilkins.

引用

页码：619 / 625

页数：7

共 91 条

[1] GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas [J].

Almeida, A ;

Zhu, XX ;

Vogt, N ;

Tyagi, R ;

Muleris, M ;

Dutrillaux, AM ;

Dutrillaux, B ;

Ross, D ;

Malfoy, B ;

Hanash, S .

ONCOGENE, 1998, 16 (23) :2997-3002

[2] THE MULTIDRUG-RESISTANCE GENE MDR1 IS EXPRESSED IN HUMAN GLIAL TUMORS [J].

BECKER, I ;

BECKER, KF ;

MEYERMANN, R ;

HOLLT, V .

ACTA NEUROPATHOLOGICA, 1991, 82 (06) :516-519

[3] DNA interstrand cross-linking and cytotoxicity induced by chloroethylnitrosoureas and cisplatin in human glioma cell lines which vary in cellular concentration of O-6-alkylguanine-DNA alkyltransferase [J].

Beith, J ;

Hartley, J ;

Darling, J ;

Souhami, R .

BRITISH JOURNAL OF CANCER, 1997, 75 (04) :500-505

[4] Genetics of pediatric central nervous system tumors [J].

Biegel, JA .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 1997, 19 (06) :492-501

[5] Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas [J].

Biernat, W ;

Tohma, Y ;

Yonekawa, Y ;

Kleihues, P ;

Ohgaki, H .

ACTA NEUROPATHOLOGICA, 1997, 94 (04) :303-309

[6]

Boström J, 1998, CANCER RES, V58, P29

[7] Chromosome arm 17p deletion analysis reveals molecular genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumors of the central nervous system [J].

Burnett, ME ;

White, EC ;

Sih, S ;

vonHaken, MS ;

Cogen, PH .

CANCER GENETICS AND CYTOGENETICS, 1997, 97 (01) :25-31

[8] The hydroxyurea-induced loss of double-minute chromosomes containing amplified epidermal growth factor receptor genes reduces the tumorigenicity and growth of human glioblastoma multiforme [J].

Canute, GW ;

Longo, SL ;

Longo, JA ;

Shetler, MM ;

Coyle, TE ;

Winfield, JA ;

Hahn, PJ .

NEUROSURGERY, 1998, 42 (03) :609-616

[9] Anti-P-glycoprotein antibody C219 cross-reactivity with c-erbB2 protein: Diagnostic and clinical implications [J].

Chan, HSL ;

Ling, V .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1997, 89 (20) :1473-1476

[10] PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas [J].

Chiariello, E ;

Roz, L ;

Albarosa, R ;

Magnani, I ;

Finocchiaro, G .

ONCOGENE, 1998, 16 (04) :541-545

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