Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds, 2014-2015

被引：43

作者：

Bi, Yuhai ^{[1
,3
,6
]}

Chen, Jianjun ^{[2
,7
]}

Zhang, Zhenjie ^{[4
]}

Li, Mingxin ^{[2
]}

Cai, Tianlong ^{[5
]}

Sharshov, Kirill ^{[7
]}

Susloparov, Ivan ^{[7
]}

Shestopalov, Alexander ^{[7
]}

Wong, Gary ^{[3
]}

He, Yubang ^{[8
]}

Xing, Zhi ^{[8
]}

Sun, Jianqing ^{[8
]}

Liu, Di ^{[3
]}

Liu, Yingxia ^{[1
]}

Liu, Lei ^{[1
]}

Liu, Wenjun ^{[3
,6
]}

Lei, Fumin ^{[5
,6
]}

Shi, Weifeng ^{[4
]}

Gao, George F. ^{[1
,3
,6
,9
,10
]}

机构：

[1] Shenzhen Third Peoples Hosp, Shenzhen Key Lab Pathogen & Immun, State Key Discipline Infect Dis, Shenzhen 518112, Peoples R China

[2] Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Peoples R China

[3] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol CASPMI, Beijing 100101, Peoples R China

[4] Taishan Med Coll, Inst Pathogen Biol, Taishan 271000, Peoples R China

[5] Chinese Acad Sci, Inst Zool, CAS Key Lab Zool Systemat & Evolut, Beijing 100101, Peoples R China

[6] Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing 100101, Peoples R China

[7] Novosibirsk State Univ, Res Inst Expt & Clin Med, Novosibirsk 630090, Russia

[8] State Forestry Adm, Qinghai Lake Natl Nat Reserve, Xining 810007, Peoples R China

[9] Zhejiang Univ, Chinese Ctr Dis Control & Prevent China CDC, Off Director Gen, Hangzhou 310058, Zhejiang, Peoples R China

[10] Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China

来源：

VIROLOGICA SINICA | 2016年 / 31卷 / 04期

基金：

中国国家自然科学基金; 加拿大健康研究院;

关键词：

H5N1; highly pathogenic avian influenza virus; Clade; 2.3.2.1c; outbreak; migratory birds; MOLECULAR-BASIS; A(H5N1) VIRUS; AMINO-ACID; A VIRUS; OUTBREAKS; HEMAGGLUTININ; VIRULENCE; POULTRY; PROTEIN;

D O I：

10.1007/s12250-016-3750-4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA, a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin. The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain (A/Alberta/01/2014). Further analysis showed that similar viruses have been circulating in wild birds in China, Russia, Dubai (Western Asia), Bulgaria and Romania (Europe), as well as domestic poultry in some regions of Africa. The affected areas include the Central Asian, East Asian-Australasian, West Asian-East African, and Black Sea/Mediterranean flyways. These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds, thus posing a serious threat to wild birds and potentially humans.

引用

页码：300 / 305

页数：6

共 27 条

[1] Highly Pathogenic Avian Influenza A(H5N1) Virus Struck Migratory Birds in China in 2015 [J].