The lung as a privileged site for the beneficial actions of PGE2

被引：270

作者：

Vancheri, C

Mastruzzo, C

Sortino, MA

Crimi, N

机构：

[1] Univ Catania, Sect Resp Dis, Dept Internal & Specialist Med, I-95125 Catania, Italy

[2] Univ Catania, Dept Expt & Clin Pharmacol, I-95125 Catania, Italy

来源：

TRENDS IN IMMUNOLOGY | 2004年 / 25卷 / 01期

关键词：

D O I：

10.1016/j.it.2003.11.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Prostaglandin E-2 (PGE(2)) is commonly considered a potent proinflammatory mediator and is involved in several inflammatory diseases. In the lung, as opposed to many other parts of the body, PGE2 has a role in limiting the immune-inflammatory response as well as tissue repair processes. Understanding the full implications of the regulatory role of PGE2 and how beneficial processes, such as inflammation and tissue repair, become dysregulated to the point of causing disease, might disclose new perspectives in the treatment of pulmonary diseases.

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收藏

页码：40 / 46

页数：7

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