Particle size dependence of relaxivity for silica-coated iron oxide nanoparticles

被引：40

作者：

Ahmad, Tanveer ^{[1
]}

Bae, Hongsub ^{[1
]}

Rhee, Ilsu ^{[1
]}

Chang, Yongmin ^{[2
]}

Lee, Jaejun ^{[2
]}

Hong, Sungwook ^{[3
]}

机构：

[1] Kyungpook Natl Univ, Dept Phys, Taegu 702701, South Korea

[2] Kyungpook Univ Hosp, Dept Radiol, Taegu 700422, South Korea

[3] Daegu Univ, Div Sci Educ, Gyongsan 712714, South Korea

来源：

CURRENT APPLIED PHYSICS | 2012年 / 12卷 / 03期

关键词：

Iron oxide nanoparticle; Silica coating; Relaxivity; Contrast agent; MRI; MAGNETIC NANOPARTICLES; CONTRAST AGENTS; FABRICATION;

D O I：

10.1016/j.cap.2011.12.020

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

relaxivityWe investigate the particle size dependence of the relaxivity of hydrogen protons in an aqueous solution of iron oxide (Fe3O4) nanoparticles coated in silica for biocompatibility. The T-1 and T-2 relaxation times for various concentrations of silica-coated nanoparticles were determined by a magnetic resonance scanner. We find that the relaxivity increased linearly with increasing particle size. The T-2 relaxivity (R-2) is more than 50 times larger than the T-1 relaxivity (R-1) for the nanoparticle contrast agent, which reflects the fact that the T-2 relaxation is mainly influenced by outer sphere processes. The high R-2/R-1 ratio demonstrates that silica-coated iron oxide nanoparticles may serve as a T-2 contrast agents in magnetic resonance imaging with high efficacy. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：969 / 974

页数：6

共 27 条

[1]

Ahmad T., 2010, NEW PHYS SAE MULLI, V60, P254

[2]

Ni-Fe2O4 Nanoparticles as Contrast Agents for Magnetic Resonance Imaging [J].