Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma and basal cell carcinoma

被引:15
作者
Choi, Chong Won [1 ]
Park, Hyun Sun [1 ]
Kim, Yeon Kyung [1 ]
Lee, Seung Ho [2 ]
Cho, Kwang Hyun [1 ]
机构
[1] Seoul Natl Univ, Coll Med, Dept Dermatol, Seoul 110744, South Korea
[2] Dongguk Univ, Coll Med, Dongguk Univ Int Hosp, Dept Dermatol, Goyang, South Korea
关键词
basal cell carcinoma; cytokeratin; 15; elastic fiber; trichoepithelioma;
D O I
10.1111/j.1346-8138.2008.00510.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 [皮肤病与性病学];
摘要
Trichoepithelioma (TE) is a benign neoplasm of the skin that resembles basal cell carcinoma (BCC) in its clinical and histological features. In this study, we evaluate the usefulness of elastic fiber staining and cytokeratin 15 expression pattern in terms of distinguishing TE from BCC. Eleven TE and 17 BCC were examined histochemically and immunohistochemically. It was found that BCC contain more elastic fiber than TE, and that more TE show peripheral localization than BCC in cytokeratin 15 expression patterns. The present study shows that elastic fiber staining and cytokeratin 15 expression pattern may aid the differentiation of TE from BCC.
引用
收藏
页码:499 / 502
页数:4
相关论文
共 18 条
[1]
Activation of expression of hedgehog target genes in basal cell carcinomas [J].
Bonifas, JM ;
Pennypacker, S ;
Chuang, PT ;
McMahon, AP ;
Williams, M ;
Rosenthal, A ;
de Sauvage, FJ ;
Epstein, EH .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 116 (05) :739-742
[2]
Eto T, 1996, CANCER, V77, P646, DOI 10.1002/(SICI)1097-0142(19960215)77:4<646::AID-CNCR10>3.0.CO
[3]
2-0
[4]
Fukushima M, 2000, PATHOL INT, V50, P1003
[5]
A basaloid neoplasm with ductal differentiation [J].
Grosshans, E ;
Misago, N ;
Yus, ES ;
Soyer, HP .
AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2003, 25 (01) :77-80
[6]
Molecular diagnosis of basal cell carcinoma and other basaloid cell neoplasms of the skin by the quantification of Gli1 transcript levels [J].
Hatta, N ;
Hirano, T ;
Kimura, T ;
Hashimoto, K ;
Mehregan, DR ;
Ansai, S ;
Takehara, K ;
Takata, M .
JOURNAL OF CUTANEOUS PATHOLOGY, 2005, 32 (02) :131-136
[7]
HUMENIUK V, 1983, CANCER, V52, P1448, DOI 10.1002/1097-0142(19831015)52:8<1448::AID-CNCR2820520818>3.0.CO
[8]
2-Z
[9]
Cytokeratin 15 expression in trichoepitheliomas and a subset of basal cell carcinomas suggests they originate from hair follicle stem cells [J].
Jih, DM ;
Lyle, S ;
Elenitsas, R ;
Elder, DE ;
Cotsarelis, G .
JOURNAL OF CUTANEOUS PATHOLOGY, 1999, 26 (03) :113-118
[10]
Kanitakis J, 1999, EUR J DERMATOL, V9, P363