CDNA cloning of a 20-kDa protein (p20) highly homologous to small heat shock proteins: Developmental and physiological changes in rat hindlimb muscles

被引：40

作者：

Inaguma, Y ^{[1
]}

Hasegawa, K ^{[1
]}

Kato, K ^{[1
]}

Nishida, Y ^{[1
]}

机构：

[1] NAGOYA UNIV, SCH SCI, DEPT BIOL, NAGOYA, AICHI 46401, JAPAN

来源：

GENE | 1996年 / 178卷 / 1-2期

关键词：

crystallin; gene family; HSP; muscle; stress protein;

D O I：

10.1016/0378-1119(96)00356-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A cDNA clone encoding p20, a novel member of the small heat-shock protein family in mammals, was isolated from a rat soleus cDNA library. The clone contained an insert of 1.3 kb with an open reading frame specifying a polypeptide of 162 amino-acid residues. Southern blot analysis suggested that the p20 gene is a single gene in rat genome. Developmental changes and a sciatic nerve denervation experiment suggested that the expression of p20 in rat hindlimb muscle is related to muscle contraction, and specifically in slow-twitch muscles.

引用

页码：145 / 150

页数：6

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