Phosphocreatine resynthesis is not affected by creatine loading

被引:87
作者
Vandenberghe, K
Van Hecke, P
Van Leemputte, M
Vanstapel, F
Hespel, P
机构
[1] Katholieke Univ Leuven, Dept Kinesiol, Fac Phys Educ & Physiotherapy, Exercise Physiol Lab, B-3001 Louvain, Belgium
[2] Katholieke Univ Leuven, Fac Med, Biomed NMR Unit, B-3001 Louvain, Belgium
关键词
P-31-NMR; ergogenics; diet; intermittent exercise;
D O I
10.1097/00005768-199902000-00006
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
Purpose: Oral creatine supplementation has been shown to improve power output during high intensity intermittent muscle contractions. Facilitated muscle phosphocreatine (PCr) resynthesis, by virtue of elevated intracellular PCr concentration, might contribute to this ergogenic action. Therefore, the effect of creatine loading (C: 25 gd(-1) for 5 d) on muscle PCr breakdown and resynthesis and muscle performance during high intensity intermittent muscle contractions was investigated. Methods: A double-blind randomized cross-over study was performed in young healthy male volunteers (N = 9). P-31-NMR spectroscopy of the m. gastrocnemius and isokinetic dynamometry of knee-extension torque were performed before and after 2 and 5 d of either placebo (P) or C administration. Results: Compared with P, 2 and 5 d of C increased (P < 0.05) resting muscle PCr concentration by 11% and 16%, respectively. Furthermore, torque production during maximal intermittent knee extensions, including the first bout of contractions, was increased (P < 0.05) by 5-13% by either 2 or 5 d of C. However, compared with P, the rate of PCr breakdown and resynthesis during intermittent isometric contractions of the calf was not significantly affected by C. Conclusion: Creatine loading raises muscle PCr concentration and improves performance during rapid and dynamic intermittent muscle contractions. Creatine loading does not facilitate muscle PCr resynthesis during intermittent isometric muscle contractions.
引用
收藏
页码:236 / 242
页数:7
相关论文
共 19 条
[1]  
Balsom P. D., 1993, Scandinavian Journal of Medicine and Science in Sports, V3, P143
[2]   CREATINE SUPPLEMENTATION PER SE DOES NOT ENHANCE ENDURANCE EXERCISE PERFORMANCE [J].
BALSOM, PD ;
HARRIDGE, SDR ;
SODERLUND, K ;
SJODIN, B ;
EKBLOM, B .
ACTA PHYSIOLOGICA SCANDINAVICA, 1993, 149 (04) :521-523
[3]   THE INFLUENCE OF DIETARY CREATINE SUPPLEMENTATION ON PERFORMANCE DURING REPEATED BOUTS OF MAXIMAL ISOKINETIC CYCLING IN MAN [J].
BIRCH, R ;
NOBLE, D ;
GREENHAFF, PL .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY, 1994, 69 (03) :268-270
[4]   Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans [J].
Casey, A ;
ConstantinTeodosiu, D ;
Howell, S ;
Hultman, E ;
Greenhaff, PL .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1996, 271 (01) :E31-E37
[5]   EFFECT OF ORAL CREATINE SUPPLEMENTATION ON POWER OUTPUT AND FATIGUE DURING BICYCLE ERGOMETRY [J].
COOKE, WH ;
GRANDJEAN, PW ;
BARNES, WS .
JOURNAL OF APPLIED PHYSIOLOGY, 1995, 78 (02) :670-673
[6]   Effect of creatine supplementation on intramuscular TCr, metabolism and performance during intermittent, supramaximal exercise in humans [J].
Febbraio, MA ;
Flanagan, TR ;
Snow, RJ ;
Zhao, S ;
Carey, MF .
ACTA PHYSIOLOGICA SCANDINAVICA, 1995, 155 (04) :387-395
[7]   INFLUENCE OF ORAL CREATINE SUPPLEMENTATION OF MUSCLE TORQUE DURING REPEATED BOUTS OF MAXIMAL VOLUNTARY EXERCISE IN MAN [J].
GREENHAFF, PL ;
CASEY, A ;
SHORT, AH ;
HARRIS, R ;
SODERLUND, K ;
HULTMAN, E .
CLINICAL SCIENCE, 1993, 84 (05) :565-571
[8]   EFFECT OF ORAL CREATINE SUPPLEMENTATION ON SKELETAL-MUSCLE PHOSPHOCREATINE RESYNTHESIS [J].
GREENHAFF, PL ;
BODIN, K ;
SODERLUND, K ;
HULTMAN, E .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (05) :E725-E730
[9]   ELEVATION OF CREATINE IN RESTING AND EXERCISED MUSCLE OF NORMAL SUBJECTS BY CREATINE SUPPLEMENTATION [J].
HARRIS, RC ;
SODERLUND, K ;
HULTMAN, E .
CLINICAL SCIENCE, 1992, 83 (03) :367-374
[10]  
HARRIS RC, 1974, SCAND J CLIN LAB INV, V33, P109