Apoptosis: Biphasic dose responses

被引：15

作者：

Calabrese, EJ ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Environm Hlth Sci, Amherst, MA 01003 USA

来源：

CRITICAL REVIEWS IN TOXICOLOGY | 2001年 / 31卷 / 4-5期

关键词：

apoptosis; cycloheximide; dimethylformamide; tumor necrosis factor alpha; staurosporine; melatonin; antidementia drugs; X-rays; hormesis; U shaped; biphasic; stimulatory; inhibitory; dose response; receptor mediated;

D O I：

10.1080/20014091111866

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 [卫生毒理学];

摘要：

The features of apoptotic dose responses typically have been evaluated over a broad dose-response continuum to differentiate apoptotic and necrotic responses. The present article specifically addresses the dose-response relationship for apoptosis in detail. It was determined that a number of well-documented cases exist in which the dose-response relationship for apoptosis is biphasic. The underlying mechanisms and biomedical implications of this biphasic dose-response phenomenon are discussed.

引用

页码：607 / 613

页数：7

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