Mitochondrial movement and inheritance in budding yeast

被引：40

作者：

Boldogh, IR ^{[1
]}

Fehrenbacher, KL ^{[1
]}

Yang, HC ^{[1
]}

Pon, LA ^{[1
]}

机构：

[1] Columbia Univ, Dept Anat & Cell Biol, New York, NY 10032 USA

来源：

GENE | 2005年 / 354卷

关键词：

actin; cytoskeleton; organelle motility; retention; retrograde flow;

D O I：

10.1016/j.gene.2005.03.049

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mitochondria are essential organelles that perform fundamental cellular functions including aerobic energy mobilization, fatty acid oxidation, amino acid metabolism, heme biosynthesis and apoptosis. Mitochondria cannot be synthesized de novo. Therefore, the inheritance of this organelle is an essential part of the cell cycle; that is, daughter cells that do not inherit mitochondria will not survive. The budding yeast, Saccharomyces cerevisiae, is a facultative aerobe that can tolerate mitochondrial mutations that would be lethal in other organisms. Therefore, yeast has been used extensively to study inheritance and segregation of mitochondria. As a result, much of what we know regarding mitochondrial inheritance has been uncovered using yeast as a model system. Here, we describe the latest developments in mitochondrial motility and inheritance. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：28 / 36

页数：9

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