Delayed cortical impairment following lipopolysaccharide exposure in preterm fetal sheep

被引：83

作者：

Dean, Justin M.

van de Looij, Yohan ^{[2
,3
]}

Sizonenko, Stephane V. ^{[2
]}

Lodygensky, Gregory A. ^{[4
]}

Lazeyras, Francois ^{[5
]}

Bolouri, Hayde

Kjellmer, Ingemar ^{[6
]}

Huppi, Petra S. ^{[2
]}

Hagberg, Henrik ^{[7
]}

Mallard, Carina ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Dept Neurosci & Physiol, Inst Neurosci & Physiol, S-40530 Gothenburg, Sweden

[2] Univ Geneva, Dept Pediat, Div Child Dev & Growth, Geneva, Switzerland

[3] Fed Polytech Sch Lausanne, Lab Funct & Metab Imaging, Lausanne, Switzerland

[4] Univ Geneva, Neonatal Intens Care Unit, Dept Pediat, Geneva, Switzerland

[5] Univ Geneva, Dept Radiol, Geneva, Switzerland

[6] Univ Gothenburg, Sahlgrenska Acad, Dept Pediat, S-40530 Gothenburg, Sweden

[7] Univ Gothenburg, Sahlgrenska Acad, Dept Obstet & Gynecol, S-40530 Gothenburg, Sweden

来源：

ANNALS OF NEUROLOGY | 2011年 / 70卷 / 05期

基金：

瑞典研究理事会;

关键词：

WHITE-MATTER INJURY; AMPLITUDE-INTEGRATED EEG; BRAIN-INJURY; SYSTEMIC ENDOTOXEMIA; PREMATURE-INFANTS; SUBPLATE NEURONS; CEREBRAL-CORTEX; NERVOUS-SYSTEM; OVINE FETUS; TERM;

D O I：

10.1002/ana.22480

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Objective: Preterm infants exhibit chronic deficits in white matter (WM) and cortical maturation. Although fetal infection/inflammation may contribute to WM pathology, the factors contributing to cortical changes are largely unknown. We examined the effect of fetal lipopolysaccharide (LPS) exposure on WM and cortical development as assessed by magnetic resonance imaging (MRI), electroencephalography (EEG), and histopathology in fetal sheep at preterm human equivalent age.

引用

页码：846 / 856

页数：11

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