The role of CD40/CD40L and interferon regulatory factor 4 in Hodgkin lymphoma microenvironment

被引：42

作者：

Aldinucci, Donatella

Gloghini, Annunziata ^{[2
]}

Pinto, Antonio ^{[3
]}

Colombatti, Alfonso

Carbone, Antonino ^{[1
]}

机构：

[1] IRCCS Natl Canc Inst, Ctr Riferimento Oncol, Div Pathol, Aviano, PN, Italy

[2] IRCCS Natl Canc Inst, Dept Pathol, Milan, Italy

[3] Fdn G Pascale, Natl Canc Inst, Hematol Oncol & Stem Cells Transplantat Unit, Naples, Italy

来源：

LEUKEMIA & LYMPHOMA | 2012年 / 53卷 / 02期

关键词：

Classical Hodgkin lymphoma; tumor microenvironment; IRF4; CD40; REED-STERNBERG CELLS; EPSTEIN-BARR-VIRUS; NF-KAPPA-B; GENE-EXPRESSION; BCL-2; EXPRESSION; CD40; LIGAND; T-CELLS; TUMOR; DISEASE; PATHWAY;

D O I：

10.3109/10428194.2011.605190

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inflammation and cancer are two independent biological events that can play an interdependent role. The model of such interaction is represented by Hodgkin lymphoma (HL), where the microenvironment is dominated by an extensive mixed, potentially cellular inflammatory infiltrate that plays a decisive role in the pathobiology of HL. In this review we summarize updated information on the complex interactions between Hodgkin Reed-Sternberg (HRS) cells and their tissue microenvironment, highlighting the functional role of CD40/CD40L and interferon regulatory factor 4 (IRF4).

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收藏

页码：195 / 201

页数：7

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