Atopic dermatitis: a disease of altered skin barrier and immune dysregulation

被引：790

作者：

Boguniewicz, Mark ^{[1
]}

Leung, Donald Y. M. ^{[1
,2
]}

机构：

[1] Natl Jewish Hlth, Div Pediat Allergy Immunol, Dept Pediat, Denver, CO 80206 USA

[2] Univ Colorado Denver, Dept Pediat, Aurora, CO USA

来源：

IMMUNOLOGICAL REVIEWS | 2011年 / 242卷

关键词：

atopic dermatitis; antimicrobial peptides; eczema herpeticum; epidermal barrier; filaggrin; Staphylococcus aureus; STAPHYLOCOCCAL-ENTEROTOXIN-B; OF-FUNCTION MUTATIONS; THYMIC STROMAL LYMPHOPOIETIN; T-CELLS; FILAGGRIN MUTATIONS; ECZEMA HERPETICUM; ICHTHYOSIS VULGARIS; VITAMIN-D; ALLERGIC SENSITIZATION; EPIDERMAL BARRIER;

D O I：

10.1111/j.1600-065X.2011.01027.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Atopic dermatitis (AD) is an important chronic or relapsing inflammatory skin disease that often precedes asthma and allergic disorders. New insights into the genetics and pathophysiology of AD point to an important role of structural abnormalities in the epidermis as well as immune dysregulation not only for this skin disease but also for the development of asthma and allergies. Patients with AD have a unique predisposition to colonization or infection by microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. Measures directed at healing and protecting the skin barrier and addressing the immune dysregulation are essential in the treatment of patients with AD, and early intervention may improve outcomes for both the skin disease as well as other target organs.

引用

页码：233 / 246

页数：14

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