Diversity of disease in childhood pulmonary tuberculosis

被引：46

作者：

Marais, BJ

Donald, PR

Gie, RP

Schaaf, S

Beyers, N

机构：

[1] Univ Stellenbosch, Fac Hlth Sci, Cape Town, South Africa

[2] Tygerberg Childrens Hosp, Dept Paediat & Child Hlth, Ctr TB Res & Educ, Cape Town, South Africa

来源：

ANNALS OF TROPICAL PAEDIATRICS | 2005年 / 25卷 / 02期

关键词：

D O I：

10.1179/146532805X45665

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Many factors can influence the dynamic balance that exists between the host and the pathogen (M. tuberculosis), but the host immune response seems to be the most important. This is illustrated by the vulnerability of immune-compromised individuals to develop tuberculosis and by the age-related spectrum of disease witnessed in immune-competent children. This age-related spectrum of disease reflects the ontogeny of the host immune response towards M. tuberculosis. Renewing our focus on the ontogeny of the immune response in children might provide valuable insights to direct future research regarding tuberculosis prevention, vaccine development and treatment.

引用

收藏

页码：79 / 86

页数：8

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