Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression

被引：53

作者：

Ballarin, Jose ^{[2
]}

Arce, Yolanda ^{[3
]}

Torra Balcells, Roser ^{[2
]}

Diaz Encarnacion, Montserrat ^{[2
]}

Manzarbeitia, Felix ^{[4
]}

Ortiz, Alberto ^{[1
]}

Egido, Jesus ^{[1
]}

Antonio Moreno, Juan ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Dept Nephrol, IIS Fdn Jimenez Diaz, Madrid, Spain

[2] Univ Autonoma Barcelona, Dept Nephrol, Fdn Puigvert, Hosp Santa Creu & Sant Pau, E-08193 Barcelona, Spain

[3] Fdn Puigvert, Dept Pathol, Barcelona, Spain

[4] IIS Fdn Jimenez Diaz, Dept Pathol, Madrid, Spain

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2011年 / 26卷 / 10期

关键词：

CD163; haemosiderin; macrophages; paroxysmal nocturnal haemoglobinuria; COMPLEMENT INHIBITOR ECULIZUMAB; SCAVENGER RECEPTOR; HEME OXYGENASE-1; KIDNEY; DISEASE;

D O I：

10.1093/ndt/gfr391

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Decreased renal function has been observed in diseases with intravascular haemolysis, including paroxysmal nocturnal haemoglobinuria (PNH). However, the mechanisms via which haemoglobin enhances renal damage in this pathology are not fully known. We report a case of acute renal failure associated to PNH and extensive haemosiderin deposits in tubular cells. Renal biopsy also revealed a strong immunostaining of CD163 (a haemoglobin scavenger receptor expressed in macrophages) and oxidative stress markers (NADPH-p22 phox and haeme oxigenase-1) in areas with deposits of iron. This fact provides evidence for a pathogenic role for free haemoglobin in tubulointerstitial renal injury in human PNH disease.

引用

页码：3408 / 3411

页数：4

共 18 条

[1]

Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria [J].

Brodsky, Robert A. ;

Young, Neal S. ;

Antonioli, Elisabetta ;

Risitano, Antonio M. ;

Schrezenmeier, Hubert ;

Schubert, Jorg ;

Gaya, Anna ;

Coyle, Luke ;

De Castro, Carlos ;

Fu, Chieh-Lin ;

Maciejewski, Jaroslaw P. ;

Bessler, Monica ;

Kroon, Henk-Andre ;

Rother, Russell P. ;

Hillmen, Peter .

BLOOD, 2008, 111 (04) :1840-1847

[2]

Reversible renal failure in paroxysmal nocturnal hemoglobinuria [J].

Chow, KM ;

Lai, FMM ;

Wang, AYM ;

Chan, YL ;

Tang, NLS ;

Li, PKT .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2001, 37 (02)

[3]

CLEARY CM, NEPHROL DIAL TRANSPL, V25, P4103

[4]

NADPH oxidases in the kidney [J].

Gill, Pritmohinder S. ;

Wilcox, Christopher S. .

ANTIOXIDANTS & REDOX SIGNALING, 2006, 8 (9-10) :1597-1607

[5]

Long-term effect of the complement inhibitor eculizumab on kidney function in patients with paroxysmal nocturnal hemoglobinuria [J].

Hillmen, Peter ;

Elebute, Modupe ;

Kelly, Richard ;

Urbano-Ispizua, Alvaro ;

Hill, Anita ;

Rother, Russell P. ;

Khursigara, Gus ;

Fu, Chieh-Lin ;

Omine, Mitsuhiro ;

Browne, Paul ;

Rosse, Wendell .

AMERICAN JOURNAL OF HEMATOLOGY, 2010, 85 (08) :553-559

[6]

Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS Clinical Trial [J].

Kanakura, Yuzuru ;

Ohyashiki, Kazuma ;

Shichishima, Tsutomu ;

Okamoto, Shinichiro ;

Ando, Kiyoshi ;

Ninomiya, Haruhiko ;

Kawaguchi, Tatsuya ;

Nakao, Shinji ;

Nakakuma, Hideki ;

Nishimura, Jun-ichi ;

Kinoshita, Taroh ;

Bedrosian, Camille L. ;

Valentine, Marye Ellen ;

Khursigara, Gus ;

Ozawa, Keiya ;

Omine, Mitsuhiro .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2011, 93 (01) :36-46

[7]

Identification of the haemoglobin scavenger receptor [J].

Kristiansen, M ;

Graversen, JH ;

Jacobsen, C ;

Sonne, O ;

Hoffman, HJ ;

Law, SKA ;

Moestrup, SK .

NATURE, 2001, 409 (6817) :198-201

[8]

Pathological mechanisms and dose dependency of erythrocyte-induced vulnerability of atherosclerotic plaques [J].

Lin, Hui-li ;

Xu, Xin-sheng ;

Lu, Hui-xia ;

Zhang, Lei ;

Li, Chang-jiang ;

Tang, Meng-xiong ;

Sun, Hui-wen ;

Liu, Yan ;

Zhang, Yun .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2007, 43 (03) :272-280

[9]

Paroxysmal nocturnal hemoglobinuria therapy with eculizumab: Spanish experience [J].

Lopez Rubio, Montserrat ;

Morado, Marta ;

Gaya, Ana ;

Alonso Rosa, Dora ;

Ojeda, Emilio ;

Antonio Munoz, Juan ;

Perez de Mendiguren, Begona ;

Dolores Monteagudo, Maria ;

Maria Duran, Jose ;

Maria Fisac, Rosa ;

Moreno, Damian ;

Maria Villegas, Ana .

MEDICINA CLINICA, 2011, 137 (01) :8-13

[10]

Nitric oxide, oxidative stress, and progression of chronic renal failure [J].

Modlinger, PS ;

Wilcox, CS ;

Aslam, S .

SEMINARS IN NEPHROLOGY, 2004, 24 (04) :354-365

← 1 2 →