Genetic characterization of H7N2 influenza virus isolated from pigs

被引:35
作者
Kwon, Tae Yong [1 ]
Lee, Sung Seok [1 ]
Kim, Chi Yong [1 ]
Shin, Jeong Yeon [1 ]
Sunwoo, Sun Young [1 ]
Lyoo, Young S. [1 ]
机构
[1] Konkuk Univ, Coll Vet Med, Immunopathol Lab, Seoul 143701, South Korea
关键词
H7N2; subtype; Reassortment; Swine influenza virus; A VIRUSES; PHYLOGENETIC ANALYSIS; SWINE; INFECTION; KOREA; PATHOGENICITY; REASSORTMENT; CHICKENS; HUMANS; ORIGIN;
D O I
10.1016/j.vetmic.2011.06.011
中图分类号
Q93 [微生物学];
学科分类号
071005 [微生物学];
摘要
Because pigs have respiratory epitheliums which express both alpha 2-3 and alpha 2-6 linked sialic acid as receptors to influenza A viruses, they are regarded as mixing vessel for the generation of pandemic influenza viruses through genetic reassortment. A H7N2 influenza virus (A/swine/KU/16/2001) was isolated from pig lungs collected from the slaughterhouse. All eight genes of the influenza virus were sequenced and phylogenetic analysis indicated that A/swine/KU/16/2001 originated in Hong Kong and genetic reassortment had occurred between the avian H7N2 and H5N3 influenza viruses. The first isolation of H7 influenza virus in pigs provides the opportunity for genetic reassortment of influenza viruses with pandemic potential and emphasizes the importance of surveillance for atypical swine influenza viruses. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:393 / 397
页数:5
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