Alarmin(g) the innate immune system to invasive fungal infections

被引：17

作者：

Caffrey, Alayna K. ^{[1
,2
]}

Obar, Joshua J. ^{[2
]}

机构：

[1] Montana State Univ, Dept Microbiol & Immunol, Bozeman, MT 59718 USA

[2] Geisel Sch Med Dartmouth, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2016年 / 32卷

关键词：

PATHOGEN ASPERGILLUS-FUMIGATUS; CHRONIC GRANULOMATOUS-DISEASE; CANDIDA-ALBICANS; NLRP3; INFLAMMASOME; PSEUDOMONAS-AERUGINOSA; EPITHELIAL-CELLS; HOST-DEFENSE; IN-VIVO; PULMONARY ASPERGILLOSIS; ATTRIBUTABLE MORTALITY;

D O I：

10.1016/j.mib.2016.06.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Fungi encounter numerous stresses in a mammalian host, including the immune system, which they must adapt to in order to grow and cause disease. The host immune system tunes its response to the threat level posed by the invading pathogen. We discuss recent findings on how interleukin (IL)-1 signaling is central to tuning the immune response to the virulence potential of invasive fungi, as well as other pathogens. Moreover, we discuss fungal factors that may drive tissue invasion and destruction that regulate IL-1 cytokine release. Moving forward understanding the mechanisms of fungal adaption to the host, together with understanding how the host innate immune system recognizes invading fungal pathogens will increase our therapeutic options for treatment of invasive fungal infections.

引用

页码：135 / 143

页数：9

共 86 条

[1]

Surface hydrophobin prevents immune recognition of airborne fungal spores [J].

Aimanianda, Vishukumar ;

Bayry, Jagadeesh ;

Bozza, Silvia ;

Kniemeyer, Olaf ;

Perruccio, Katia ;

Elluru, Sri Ramulu ;

Clavaud, Cecile ;

Paris, Sophie ;

Brakhage, Axel A. ;

Kaveri, Srini V. ;

Romani, Luigina ;

Latge, Jean-Paul .

NATURE, 2009, 460 (7259) :1117-1121

[2]

Distinct Contributions of Interleukin-1α (IL-1α) and IL-1β to Innate Immune Recognition of Pseudomonas aeruginosa in the Lung [J].

Al Moussawi, Khatoun ;

Kazmierczak, Barbara I. .

INFECTION AND IMMUNITY, 2014, 82 (10) :4204-4211

[3]

Genetic and virulence variation in an environmental population of the opportunistic pathogen Aspergillus fumigatus [J].

Alshareef, Fadwa ;

Robson, Geoffrey D. .

MICROBIOLOGY-SGM, 2014, 160 :742-751

[4]

A comparative study of the local cytokine response in the lungs of pigs experimentally infected with different PRRSV-1 strains: Upregulation of IL-1α in highly pathogenic strain induced lesions [J].

Amarilla, Shyrley P. ;

Gomez-Laguna, Jaime ;

Carrasco, Librado ;

Rodriguez-Gomez, Irene M. ;

Caridad Y Ocerin, Jose M. ;

Morgan, Sophie B. ;

Graham, Simon P. ;

Frossard, Jean-Pierre ;

Drew, Trevor W. ;

Salguero, Francisco J. .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2015, 164 (3-4) :137-147

[5]

Isolate-Dependent Growth, Virulence, and Cell Wall Composition in the Human Pathogen Aspergillus fumigatus [J].

Amarsaikhan, Nansalmaa ;

O'Dea, Evan M. ;

Tsoggerel, Angar ;

Owegi, Henry ;

Gillenwater, Jordan ;

Templeton, Steven P. .

PLOS ONE, 2014, 9 (06)

[6]

NADPH oxidase controls neutrophilic response to sterile inflammation in mice by regulating the IL-1α/G-CSF axis [J].

Bagaitkar, Juhi ;

Pech, Nancy K. ;

Ivanov, Stoyan ;

Austin, Anthony ;

Zeng, Melody Yue ;

Pallat, Sabine ;

Huang, Guangming ;

Randolph, Gwendalyn J. ;

Dinauer, Mary C. .

BLOOD, 2015, 126 (25) :2724-2733

[7]

Differences in patterns of infection and inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis [J].

Balloy, V ;

Huerre, M ;

Latgé, JP ;

Chignard, M .

INFECTION AND IMMUNITY, 2005, 73 (01) :494-503

[8]

IL-1α Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo [J].

Barry, Kevin C. ;

Fontana, Mary F. ;

Portman, Jonathan L. ;

Dugan, Aisling S. ;

Vance, Russell E. .

JOURNAL OF IMMUNOLOGY, 2013, 190 (12) :6329-6339

[9]

Nanoscale biophysical properties of the cell surface galactosaminogalactan from the fungal pathogen Aspergillus fumigatus [J].

Beaussart, Audrey ;

El-Kirat-Chatel, Sofiane ;

Fontaine, Thierry ;

Latge, Jean-Paul ;

Dufrene, Yves F. .

NANOSCALE, 2015, 7 (36) :14996-15004

[10]

The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo [J].

Bellocchio, S ;

Montagnoli, C ;

Bozza, S ;

Gaziano, R ;

Rossi, G ;

Mambula, SS ;

Vecchi, A ;

Mantovani, A ;

Levitz, SM ;

Romani, L .

JOURNAL OF IMMUNOLOGY, 2004, 172 (05) :3059-3069

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