A convenient procedure for the solution phase preparation of 2-aminothiazole combinatorial libraries

被引：108

作者：

Bailey, N ^{[1
]}

Dean, AW ^{[1
]}

Judd, DB ^{[1
]}

Middlemiss, D ^{[1
]}

Storer, R ^{[1
]}

Watson, SP ^{[1
]}

机构：

[1] GLAXOWELLCOME MED RES CTR,STEVENAGE SG1 2NY,HERTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 12期

关键词：

D O I：

10.1016/0960-894X(96)00241-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A convenient procedure for the solution phase preparation of 2-aminothiazole combinatorial libraries is described. The library preparation is simple, practical, and effective, generating compounds based around a known pharmacophore in high yield and purity. Furthermore, the procedure tolerates a diverse range of functionality in its substrates and is notable in allowing the preparation of compounds containing both free acids and bases without recourse to protection. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1409 / 1414

页数：6

共 14 条

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