Immunoglobulin G isotype responses to variant surface antigens of Plasmodium falciparum in healthy gabonese adults and children during and after successive malaria attacks

被引:20
作者
Cabrera, G
Yone, C
Tebo, AE
van Aaken, J
Lell, B
Kremsner, PG
Luty, AJF
机构
[1] Univ Tubingen, Inst Trop Med, Dept Parasitol, D-72074 Tubingen, Germany
[2] Albert Schweitzer Hosp, Med Res Unit, Lambarene, Gabon
关键词
D O I
10.1128/IAI.72.1.284-294.2004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We assessed immunoglobulin G (IgG) isotype responses with specificity for the variant surface antigens (VSA) of heterologous Plasmodium falciparum isolates by using flow cytometry and plasma from healthy Gabonese adults and from children during and after two consecutive malaria episodes. The individual isolate-specific antibody profiles differed markedly in terms of their isotype content but were similar for healthy adults and healthy uninfected children. In healthy adults, IgG3 and IgG2 responses were the highest, while in healthy children, IgG3 and IgG4 predominated. A transiently elevated IgG1 response was observed during the second of two successive malaria episodes in children, signaling P. falciparum infection-induced cross-reactive anti-VSA responses. Our findings highlight the prominence of IgG3 in the overall profile of these responses but also indicate a marked age-related increase in the prevalence of anti-VSA antibodies of the classically noncytophilic IgG2 isotype, possibly reflecting the high frequency of the histidine-131 variant of FcgammaRIIA in the Gabonese population.
引用
收藏
页码:284 / 294
页数:11
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