Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

被引：277

作者：

Rabbani, Piul ^{[1
,2
]}

Takeo, Makoto ^{[1
,2
]}

Chou, WeiChin ^{[1
,2
]}

Myung, Peggy ^{[3
]}

Bosenberg, Marcus ^{[4
]}

Chin, Lynda ^{[5
]}

Taketo, M. Mark ^{[6
]}

Ito, Mayumi ^{[1
,2
]}

机构：

[1] NYU, Sch Med, Dept Dermatol, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA

[3] Univ Hosp Case Western Reserve, Dept Dermatol, Cleveland, OH USA

[4] Yale Univ, Sch Med, Dept Dermatol, New Haven, CT 06510 USA

[5] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[6] Kyoto Univ, Dept Pharmacol, Grad Sch Med, Kyoto 6068501, Japan

来源：

CELL | 2011年 / 145卷 / 06期

关键词：

BETA-CATENIN; NEURAL CREST; FOLLICLE MORPHOGENESIS; TRANSCRIPTION FACTOR; SKIN; GROWTH; DIFFERENTIATION; EXPRESSION; NICHE; CYCLE;

D O I：

10.1016/j.cell.2011.05.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Melanocyte stem cells (McSCs) intimately interact with epithelial stem cells (EpSCs) in the hair follicle bulge and secondary hair germ (sHG). Together, they undergo activation and differentiation to regenerate pigmented hair. However, the mechanisms behind this coordinated stem cell behavior have not been elucidated. Here, we identified Wnt signaling as a key pathway that couples the behavior of the two stem cells. EpSCs and McSCs coordinately activate Wnt signaling at the onset of hair follicle regeneration within the sHG. Using genetic mouse models that specifically target either EpSCs or McSCs, we show that Wnt activation in McSCs drives their differentiation into pigment-producing melanocytes, while EpSC Wnt signaling not only dictates hair follicle formation but also regulates McSC proliferation during hair regeneration. Our data define a role for Wnt signaling in the regulation of McSCs and also illustrate a mechanism for regeneration of complex organs through collaboration between heterotypic stem cell populations.

引用

页码：941 / 955

页数：15

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