Synthesis and in vitro study of novel 7-O-acyl derivatives of Oroxylin A as antibacterial agents

被引：42

作者：

Babu, KS

Babu, TH

Srinivas, PV

Sastry, BS

Kishore, KH

Murty, USN

Rao, JM ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem 1, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Div Biol, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 17期

关键词：

Oroxylin A; acylation; antibacterial activity; Oroxylum indicum;

D O I：

10.1016/j.bcml.2005.05.045

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of Oroxylin A derivatives, prepared by alkylation and condensation, were fully characterized by spectroscopic methods. All the derivatives were screened for antibacterial activity against a panel of susceptible and resistant Gram-positive and Gram-negative organisms. It was observed that acylation of 7-OH group in Oroxylin A significantly enhanced the activity as compared to their parent compound (Oroxylin A). (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：3953 / 3956

页数：4

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