Effects of antipsychotic treatment on emotion perception deficits in first-episode schizophrenia

被引:83
作者
Herbener, ES [1 ]
Hill, SK [1 ]
Marvin, RW [1 ]
Sweeney, JA [1 ]
机构
[1] Univ Illinois, Dept Psychiat, Ctr Cognit Med, Chicago, IL 60612 USA
关键词
D O I
10.1176/appi.ajp.162.9.1746
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: The authors evaluated emotion perception in acutely ill patients experiencing a first episode of schizophrenia. They also investigated the effects of antipsychotic medication on emotion perception. Method: Tests of the ability to perceive and discriminate emotional expressions from the Penn Computerized Neuropsychological Battery were given to 13 patients experiencing their first episode of schizophrenia. Patients were also assessed with the Positive and Negative Syndrome Scale. The patients were tested while they were unmedicated and again following clinical stabilization. Healthy individuals were evaluated over a similar time interval. Results: Patients with first-episode schizophrenia demonstrated impairments in emotion perception before treatment and no significant improvement after treatment. Emotion perception deficits were correlated with negative symptoms after clinical stabilization. Conclusions: Deficits in emotion perception are present at illness onset in schizophrenia and show minimal response to effective antipsychotic treatment.
引用
收藏
页码:1746 / 1748
页数:3
相关论文
共 13 条
[1]  
[Anonymous], 1986, POSITIVE NEGATIVE SY
[2]  
Bleuler E., 1950, DEMENTIA PRAECOX GRO
[3]   FACIAL EMOTION DISCRIMINATION .1. TASK CONSTRUCTION AND BEHAVIORAL FINDINGS IN NORMAL SUBJECTS [J].
ERWIN, RJ ;
GUR, RC ;
GUR, RE ;
SKOLNICK, B ;
MAWHINNEYHEE, M ;
SMAILIS, J .
PSYCHIATRY RESEARCH, 1992, 42 (03) :231-240
[4]  
Green MF, 1997, AM J PSYCHIAT, V154, P799
[5]  
GUR RC, COMPUTERIZED NEUROPS
[6]   Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naive patients with schizophrenia [J].
Hill, SK ;
Schuepbach, D ;
Herbener, ES ;
Keshavan, MS ;
Sweeney, JA .
SCHIZOPHRENIA RESEARCH, 2004, 68 (01) :49-63
[7]  
Hoff AL, 1999, AM J PSYCHIAT, V156, P1336
[8]   Risperidone versus haloperidol for perception of emotion in treatment-resistant schizophrenia: preliminary findings [J].
Kee, KS ;
Kern, RS ;
Marshall, BD ;
Green, MF .
SCHIZOPHRENIA RESEARCH, 1998, 31 (2-3) :159-165
[9]   The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: A review and meta-analysis [J].
Keefe, RSE ;
Silva, SG ;
Perkins, DO ;
Lieberman, JA .
SCHIZOPHRENIA BULLETIN, 1999, 25 (02) :201-222
[10]  
Psychological Corporation, 1999, WECHSL ABBR SCAL INT