Quantitative EEG in early Alzheimer's disease patients - Power spectrum and complexity features

被引：121

作者：

Czigler, Balazs ^{[1
]}

Csikos, Dora ^{[1
]}

Hidasi, Zoltan ^{[2
]}

Gaal, Zsofia Anna ^{[1
]}

Csibri, Eva ^{[2
]}

Kiss, Eva ^{[3
]}

Salacz, Pal ^{[2
]}

Molnar, Mark ^{[1
]}

机构：

[1] Hungarian Acad Sci, Inst Psychol, H-1394 Budapest, Hungary

[2] Semmelweis Univ Med Sch, Dept Psychiat, Budapest, Hungary

[3] Natl Inst Psychiat & Neurol, Budapest, Hungary

来源：

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY | 2008年 / 68卷 / 01期

基金：

匈牙利科学研究基金会;

关键词：

Alzheimer's disease; quantitative EEG; nonlinear dynamics; omega-complexity; synchronization likelihood;

D O I：

10.1016/j.ijpsycho.2007.11.002

中图分类号：

B84 [心理学];

学科分类号：

04 [教育学]; 0402 [心理学];

摘要：

The goal of this study was to investigate the EEG signs of early stage Alzheimer's disease (AD) by conventional analyses and by methods quantifying linear and nonlinear EEG-complexity. The EEG was recorded in 12 mild AD patients and in an age-matched healthy control group (24 subjects) in both eyes open and eyes closed conditions. Frequency spectra, Omega-complexity and Synchronization likelihood were calculated on the data. In the patients a significant decrease of the relative alpha and increase of the theta power were found. Remarkably increased Omega-complexity and lower Synchronization likelihood were observed in AD in the 0.5-25 Hz frequency ranges. It is concluded that both spectral- and EEG-complexity changes can be found already in the early stage of AD in a wide frequency range. Application of conventional EEG analysis methods in combination with quantification of EEG-complexity may improve the chances of early diagnosis of AD. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：75 / 80

页数：6

共 35 条

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Analysis of EEG background activity in Alzheimer's disease patients with Lempel-Ziv complexity and central tendency measure [J].