Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390

被引：11

作者：

Barboni, L

Ballini, R

Giarlo, G

Appendino, G

Fontana, G

Bombardelli, E

机构：

[1] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, Italy

[2] Univ Piemonte Orientale, Dipartimento Sci Chim Alimentari Farmaceut & Farm, I-28100 Novara, Italy

[3] Indena SpA, I-20139 Milan, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 23期

关键词：

paclitaxel; IDN5109; IDN5390; methoxylated; newer generation taxoids;

D O I：

10.1016/j.bmcl.2005.08.066

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Starting from 10-deacetylbaccatin 111 (7), the 2-debenzoyl-2-m-methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation anticancer taxanes. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：5182 / 5186

页数：5

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