Exhaled nitric oxide after β2-agonist inhalation and spirometry in asthma

被引:128
作者
Silkoff, PE
Wakita, S
Chatkin, J
Ansarin, K
Gutierrez, C
Caramori, M
McClean, P
Slutsky, AS
Zamel, N
Chapman, KR
机构
[1] Univ Toronto, Fac Med, Div Resp Med, Toronto, ON, Canada
[2] Natl Jewish Med & Res Ctr, Denver, CO USA
[3] Pontificia Univ Catolica Rio Grande do Sul, Porto Alegre, RS, Brazil
关键词
D O I
10.1164/ajrccm.159.3.9805044
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Exhaled nitric oxide (ENO) is used increasingly as a surrogate marker of airway inflammation in research protocols that may incorporate standard efficacy measures such as spirometry before and after bronchodilator, which could affect ENO measurements. In seven healthy volunteers and 11 mild asthmatic subjects, we measured ENO before and serially for 1 h after spirometry. On two additional days in the subjects with asthma, we reexamined the effect of spirometry as before, followed by the serial measurement of ENO for 1 h after two puffs of salbutamol (100 mu g/puff) by metered-dose inhaler or matching placebo. As early as 1 min after spirometry, ENO fell by 13% and 10% in the normal and asthmatic subjects, respectively. In both groups, ENO returned to baseline over 1 h. In the asthmatic subjects, salbutamol caused a significant mean increase of the order of 10 parts per billion in ENO (p < 0.001) for 1 h as compared with placebo inhaler. We conclude that spirometry and beta(2)-agonist may perturb ENO values and recommend that studies control for these factors.
引用
收藏
页码:940 / 944
页数:5
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