Evidence for a Common Evolutionary Origin of Coronavirus Spike Protein Receptor-Binding Subunits

被引：114

作者：

Li, Fang ^{[1
]}

机构：

[1] Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 05期

关键词：

CRYSTAL-STRUCTURE; CORE;

D O I：

10.1128/JVI.06882-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Among different coronavirus genera, the receptor-binding S1 subunits of their spike proteins differ in primary, secondary, and tertiary structures. This study identified shared structural topologies (connectivity of secondary structural elements) in S1 domains of different coronavirus genera. The results suggest that coronavirus S1 subunits share a common evolutionary origin but have attained diverse sequences and structures following extensive divergent evolution. The results also increase understanding of the structures and functions of coronavirus SI domains whose tertiary structures are currently unknown.

引用

页码：2856 / 2858

页数：3

共 11 条

[1] A new bioinformatics analysis tools framework at EMBL-EBI [J].

Goujon, Mickael ;

McWilliam, Hamish ;

Li, Weizhong ;

Valentin, Franck ;

Squizzato, Silvano ;

Paern, Juri ;

Lopez, Rodrigo .

NUCLEIC ACIDS RESEARCH, 2010, 38 :W695-W699

[2] Touring protein fold space with Dali/FSSP [J].

Holm, L ;

Sander, C .

NUCLEIC ACIDS RESEARCH, 1998, 26 (01) :316-319

[3] Structure of SARS coronavirus spike receptor-binding domain complexed with receptor [J].

Li, F ;

Li, WH ;

Farzan, M ;

Harrison, SC .

SCIENCE, 2005, 309 (5742) :1864-1868

[4] Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor [J].

Peng, Guiqing ;

Sun, Dawei ;

Rajashankar, Kanagalaghatta R. ;

Qian, Zhaohui ;

Holmes, Kathryn V. ;

Li, Fang .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (26) :10696-10701

[5] Coronaviruses post-SARS: update on replication and pathogenesis [J].

Perlman, Stanley ;

Netland, Jason .

NATURE REVIEWS MICROBIOLOGY, 2009, 7 (06) :439-450

[6] Sialic acids as receptor determinants for coronaviruses [J].

Schwegmann-Wessels, C ;

Herrler, G .

GLYCOCONJUGATE JOURNAL, 2006, 23 (1-2) :51-58

[7] Binding of Avian Coronavirus Spike Proteins to Host Factors Reflects Virus Tropism and Pathogenicity [J].

Wickramasinghe, I. N. Ambepitiya ;

de Vries, R. P. ;

Grone, A. ;

de Haan, C. A. M. ;

Verheije, M. H. .

JOURNAL OF VIROLOGY, 2011, 85 (17) :8903-8912

[8] A Virus-Binding Hot Spot on Human Angiotensin-Converting Enzyme 2 Is Critical for Binding of Two Different Coronaviruses [J].

Wu, Kailang ;

Chen, Lang ;

Peng, Guiqing ;

Zhou, Wenbo ;

Pennell, Christopher A. ;

Mansky, Louis M. ;

Geraghty, Robert J. ;

Li, Fang .

JOURNAL OF VIROLOGY, 2011, 85 (11) :5331-5337

[9] Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor [J].

Wu, Kailang ;

Li, Weikai ;

Peng, Guiqing ;

Li, Fang .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (47) :19970-19974

[10] Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core [J].

Xu, YH ;

Lou, ZY ;

Liu, YW ;

Pang, H ;

Tien, P ;

Gao, GF ;

Rao, ZH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (47) :49414-49419

← 1 2 →